Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs
| العنوان: | Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs |
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| المؤلفون: | Paolo De Paoli, Massimo Genovese, Anna Caselli, Ilaria Nesi |
| المصدر: | Molecules Molecules, Vol 26, Iss 4818, p 4818 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmaceutical Science, Review, Type 2 diabetes, Pharmacology, Analytical Chemistry, QD241-441, Diabetes mellitus, Drug Discovery, medicine, Humans, Hypoglycemic Agents, Glycoside Hydrolase Inhibitors, Enzyme Inhibitors, Physical and Theoretical Chemistry, insulin signaling, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Drug discovery, business.industry, α glucosidase, Organic Chemistry, PTP1B, alpha-Glucosidases, medicine.disease, Protein Tyrosine Phosphatase 1B, Insulin receptor, Diabetes Mellitus, Type 2, Chemistry (miscellaneous), Biological target, biology.protein, Molecular Medicine, α-glucosidase, type 2 diabetes, business |
| الوصف: | Diabetes mellitus (DM) represents a group of metabolic disorders that leads to acute and long-term serious complications and is considered a worldwide sanitary emergence. Type 2 diabetes (T2D) represents about 90% of all cases of diabetes, and even if several drugs are actually available for its treatment, in the long term, they show limited effectiveness. Most traditional drugs are designed to act on a specific biological target, but the complexity of the current pathologies has demonstrated that molecules hitting more than one target may be safer and more effective. The purpose of this review is to shed light on the natural compounds known as α-glucosidase and Protein Tyrosine Phosphatase 1B (PTP1B) dual-inhibitors that could be used as lead compounds to generate new multitarget antidiabetic drugs for treatment of T2D. |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5114694eaf3e82744790a14ed3fe9dTest https://doi.org/10.3390/molecules26164818Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cf5114694eaf3e82744790a14ed3fe9d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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