Acetaminophen metabolism after major surgery: a greater challenge with increasing age
| العنوان: | Acetaminophen metabolism after major surgery: a greater challenge with increasing age |
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| المؤلفون: | Estelle Simen, Claude Dubray, Isabelle Papet, E Schneider, Pierre Schoeffler, Gisèle Pickering, Bruno Pereira, Estelle Pujos-Guillot |
| المساهمون: | CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), We thank all persons who collaborated in the study, especially Francoise Glomot, for glutathione measurements, and Bernard Lyan, for quantification of APAP metabolites. This study was supported by a clinical research allowance from the French Ministry of Health., Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université |
| المصدر: | Clinical Pharmacology and Therapeutics Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2011, 90 (5), pp.707-711. ⟨10.1038/clpt.2011.176⟩ |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Aging, Antioxidant, [SDV]Life Sciences [q-bio], Urinary system, medicine.medical_treatment, Oxidative phosphorylation, Pharmacology, pharmacology and pharmacy, surgery, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, detoxification, 030304 developmental biology, Acetaminophen, Aged, 0303 health sciences, Analysis of Variance, hepatic metabolism, acetaminophen (APAP), business.industry, digestive, oral, and skin physiology, Age Factors, Glutathione, Metabolism, Analgesics, Non-Narcotic, Middle Aged, 3. Good health, Surgery, chemistry, Liver, 030220 oncology & carcinogenesis, Surgical Procedures, Operative, Female, business, Glucuronide, Oxidation-Reduction, Drug metabolism, medicine.drug, Follow-Up Studies |
| الوصف: | International audience; Patients undergoing major surgery represent a good model for the study of the hepatic metabolism of acetaminophen (APAP) after surgery and for the evaluation of how the detoxification process is influenced by aging. Thirty patients received intravenous APAP (1 g/6 h) for 4 days (D1–D4). Daily 24-h urinary metabolites—cysteine–APAP, mercapturate–APAP, APAP, and glucuronide and sulfate conjugates—as well as blood glutathione levels were compared with repeated-measures analysis of variance (significance, P < 0.05). Between D1 and D4, cysteine–APAP increased (308 ± 308 mg vs. 570 ± 512 mg, P = 0.005), and sulfate and glucuronide conjugates decreased (1,365 ± 1,084 mg vs. 694 ± 600 mg, P < 0.0001 and 2,418 ± 817 mg vs. 1,513 ± 1,076 mg, P = 0.011, respectively). Blood glutathione decreased (790 ± 125 vs. 623 ± 132 µmol/l, P < 0.0001. These changes increased with aging. APAP disposition after major surgery shifts toward the oxidative pathways of metabolism, and this is enhanced with aging. Supplementation with sulfur-containing amino acids should be investigated further as it might minimize the effect on antioxidant defenses, especially in older persons undergoing more extensive surgical procedures. |
| تدمد: | 1532-6535 0009-9236 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3caa2c7e2911cb26fd42cf5e17f131Test https://pubmed.ncbi.nlm.nih.gov/21975347Test |
| رقم الانضمام: | edsair.doi.dedup.....cf3caa2c7e2911cb26fd42cf5e17f131 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15326535 00099236 |
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