Effects of HIV-1 genotype on baseline CD4+ cell count and mortality before and after antiretroviral therapy
| العنوان: | Effects of HIV-1 genotype on baseline CD4+ cell count and mortality before and after antiretroviral therapy |
|---|---|
| المؤلفون: | Qiuying Zhu, Guanghua Lan, Huanhuan Chen, Yi Feng, Yiming Shao, Xinjuan Zhou, Zhiyong Shen, Shujia Liang, Yuhua Ruan, Jianjun Li, Lingjie Liao, Zhiqiang Cao, Chang Song, Hui Xing |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Adolescent, Genotype, Human immunodeficiency virus (HIV), lcsh:Medicine, HIV Infections, medicine.disease_cause, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Medical research, Internal medicine, Medicine, Humans, In patient, 030212 general & internal medicine, Cd4 cell count, lcsh:Science, Multidisciplinary, business.industry, Proportional hazards model, lcsh:R, Significant difference, Hazard ratio, virus diseases, Middle Aged, Antiretroviral therapy, CD4 Lymphocyte Count, Computational biology and bioinformatics, 030104 developmental biology, Anti-Retroviral Agents, Risk factors, HIV-1, lcsh:Q, Female, business |
| الوصف: | To assess whether human immunodeficiency virus type 1 (HIV-1) genotype influences baseline CD4+ T lymphocyte (CD4+) cell count and mortality of patients. The study was conducted from 2014 to 2019 in Guangxi, China, and included 2845 newly diagnosed HIV patients. We used a median regression model to compare CD4+ cell counts in patients newly diagnosed with different HIV-1 genotypes, and a Cox regression model to analyze the associations between HIV-1 genotypes and mortality before and after antiretroviral treatment (ART). In newly diagnosed HIV patients, the baseline CD4+ cell counts of patients with CRF01_AE were significantly lower than those of patients with CRF07_BC, CRF08_BC, and other genotypes. Compared with CRF01_AE, patients infected with CRF07_BC (hazard ratio, 0.55; 95% CI 0.36–0.85), CRF08_BC (hazard ratio, 0.67; 95% CI 0.52–0.85), or other genotypes (hazard ratio, 0.52; 95% CI 0.29–0.94) had significantly lower mortality rates before ART. There were no significant associations between different HIV-1 genotypes and mortality after ART. HIV-1 genotype significantly influences baseline CD4+ cell count and mortality before ART in newly diagnosed HIV patients. We find no significant difference in the outcome of death after ART in patients with different HIV-1 genotypes. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef29d367f431e7591e06d5e700c90f5Test https://pubmed.ncbi.nlm.nih.gov/32985559Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cef29d367f431e7591e06d5e700c90f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|