Bifid T waves on the ECG and genetic variation in calcium channel voltage‐dependent beta 2 subunit gene ( CACNB2 ) in acute Kawasaki disease
| العنوان: | Bifid T waves on the ECG and genetic variation in calcium channel voltage‐dependent beta 2 subunit gene ( CACNB2 ) in acute Kawasaki disease |
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| المؤلفون: | Chisato Shimizu, Eileen Png, Jane C. Burns, Jun Oyamada, Martin L. Hibberd, Matthew R. Williams, James C. Perry, Adriana H. Tremoulet, Jihoon Kim |
| المصدر: | Congenital Heart Disease. 14:213-220 |
| بيانات النشر: | Computers, Materials and Continua (Tech Science Press), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Calcium Channels, L-Type, Genome-wide association study, Mucocutaneous Lymph Node Syndrome, 030204 cardiovascular system & hematology, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), 030225 pediatrics, Internal medicine, T wave, Genetic variation, Genotype, medicine, Humans, Repolarization, Genetic Predisposition to Disease, Radiology, Nuclear Medicine and imaging, Polymorphism, Genetic, Voltage-dependent calcium channel, business.industry, Calcium channel, Genetic Variation, Infant, General Medicine, Endocrinology, Echocardiography, Child, Preschool, Acute Disease, Pediatrics, Perinatology and Child Health, Female, Surgery, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, Genome-Wide Association Study |
| الوصف: | Author(s): Oyamada, Jun; Shimizu, Chisato; Kim, Jihoon; Williams, Matthew R; Png, Eileen; Hibberd, Martin L; Tremoulet, Adriana H; Perry, James C; Burns, Jane C | Abstract: BackgroundWe previously described the association of genetic variants in calcium channel genes and susceptibility to Kawasaki disease (KD), an acute, self-limited vasculitis, and the most common cause of acquired cardiac disease in children. Abnormal repolarization of cardiomyocytes and changes in T wave morphology have been reported in KD but have not been studied systematically.MethodsWe analyzed acute and convalescent ECG T wave morphology in two independent cohorts of KD subjects and studied the association between bifid T waves and genetic variants in previously reported genes with SNVs associated with cardiac repolarization.ResultsBifid T waves in limb leads were identified in 24% and 27% of two independent cohorts of acute KD subjects. Calcium channel voltage-dependent beta 2 subunit gene (CACNB2) (rs1409207) showed association with bifid T waves in both cohorts (nominal P = .04 and P = .0003, respectively). This CACNB2 polymorphism also showed association with KD susceptibility in a previously published KD genome wide association study data (nominal P = .009).ConclusionThis genotype/phenotype association study uncovered a variant in CACNB2 that may be associated with both KD susceptibility and bifid T waves, a novel signature of altered myocardial repolarization. The present study combined with published reports suggests that genetic variants in calcium channels and intracellular calcium signaling play a prominent role in shaping susceptibility to KD. |
| تدمد: | 1747-0803 1747-079X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4fd50ce0e0045d3b37276759bbe2c3Test https://doi.org/10.1111/chd.12696Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ce4fd50ce0e0045d3b37276759bbe2c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17470803 1747079X |
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