The Association of Alanine Aminotransferase in Early Pregnancy with Gestational Diabetes
| العنوان: | The Association of Alanine Aminotransferase in Early Pregnancy with Gestational Diabetes |
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| المؤلفون: | Chloe Zera, David E. Cantonwine, Christina D. Yarrington, Thomas F. McElrath, Ellen W. Seely |
| المصدر: | Metabolic Syndrome and Related Disorders. 14:254-258 |
| بيانات النشر: | Mary Ann Liebert Inc, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Body Mass Index, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Pregnancy, Diabetes mellitus, Internal medicine, Odds Ratio, Prevalence, Internal Medicine, Humans, Medicine, Longitudinal Studies, Obesity, Prospective Studies, 030212 general & internal medicine, biology, business.industry, Obstetrics, Fatty liver, nutritional and metabolic diseases, Type 2 Diabetes Mellitus, Alanine Transaminase, Odds ratio, Glucose Tolerance Test, medicine.disease, Gestational diabetes, Diabetes, Gestational, Diabetes Mellitus, Type 1, Endocrinology, Diabetes Mellitus, Type 2, Liver, Alanine transaminase, Case-Control Studies, biology.protein, Regression Analysis, Female, Insulin Resistance, business, Body mass index |
| الوصف: | Elevated alanine amino transferase, attributed to nonalcoholic fatty liver, is associated with later development of type 2 diabetes mellitus. We sought to determine whether maternal ALT values are associated with subsequent development of gestational diabetes.We performed a nested case-control study utilizing prospectively banked serum samples collected in early gestation. We excluded women with known diabetes, liver disease, or alcohol use. We included 83 cases of gestational diabetes mellitus (GDM) and 247 controls matched for prepregnancy body-mass index (BMI) and compared ALT values. We then performed a conditional logistic regression to model the adjusted odds of GDM in women with ALT ≥19 U/L, stratified by prepregnancy BMI.The median (interquartile range) ALT in cases was 15 (12, 19) IU/L compared to 13 (11, 18) IU/L in controls (P = 0.07). Among women with a prepregnancy BMI30 kg/m(2), ALT ≥19 U/L was associated with a fourfold increased odds of GDM (adjusted odds ratio [aOR] 4.56 [1.45, 14.27]), while there was no such association among obese women (aOR 0.36 [0.11, 1.20]). Similarly, each unit increase in log-transformed ALT was associated with a threefold increased odds of GDM in nonobese (aOR 3.15 [1.04,9.54]), but not obese (aOR 3.15 [0.30,3.15]) women.The association of high normal ALT and later GDM in nonobese women may reflect the role of hepatic insulin resistance and visceral obesity. |
| تدمد: | 1557-8518 1540-4196 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1705b4982b9bc6668ee190723ca695Test https://doi.org/10.1089/met.2015.0106Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ce1705b4982b9bc6668ee190723ca695 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578518 15404196 |
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