التفاصيل البيبلوغرافية
العنوان:
Concomitant oral tyrosine kinase inhibitors and bisphosphonates in advanced renal cell carcinoma with bone metastases
المؤلفون:
Pascal Wolter , Alexandra Karadimou , Jean-Jacques Body , Patrick Schöffski , H. Van Poppel , Ludo Willems , Benoit Beuselinck , Philip R. Debruyne , Annick Rogiers , T. van Cann , R. Elaidi , Robert Paridaens , Herlinde Dumez , Joost Berkers , Evelyne Lerut
المصدر:
British Journal of Cancer
سنة النشر:
2012
مصطلحات موضوعية:
Male , Cancer Research , Pathology , Diphosphonates -- administration & dosage -- adverse effects , Indoles , Phenylurea Compounds -- administration & dosage , Antineoplastic Combined Chemotherapy Protocols -- adverse effects -- therapeutic use , Targeted therapy , bone metastases , Renal cell carcinoma , Antineoplastic Combined Chemotherapy Protocols , Bone Density Conservation Agents -- administration & dosage -- adverse effects , Bone Neoplasms -- drug therapy -- pathology -- secondary , Sunitinib , Neoplasm Metastasis , Indoles -- administration & dosage , Outcome , Bone Density Conservation Agents , Diphosphonates , Protein Kinase Inhibitors -- administration & dosage , Osteonecrosis , Bisphosphonates , Sciences bio-médicales et agricoles , Middle Aged , Protein-Tyrosine Kinases , Sorafenib , Prognosis , targeted therapy , Kidney Neoplasms , Treatment Outcome , Oncology , outcome , Female , Niacinamide -- administration & dosage -- analogs & derivatives , Tyrosine kinase , medicine.drug , Carcinoma, Renal Cell -- drug therapy -- pathology -- secondary , Niacinamide , medicine.medical_specialty , renal cell carcinoma , Bone Neoplasms , Osteonecrosis -- chemically induced , Disease-Free Survival , Kidney Neoplasms -- drug therapy -- pathology , Pyrroles -- administration & dosage , medicine , Carcinoma , Humans , Pyrroles , Carcinoma, Renal Cell , Protein Kinase Inhibitors , bisphosphonates , Retrospective Studies , Osteonecrosis of the jaw , business.industry , Protein-Tyrosine Kinases -- antagonists & inhibitors , Bone metastases , Phenylurea Compounds , medicine.disease , osteonecrosis of the jaw , Concomitant , Cancer research , Clinical Study , business
الوصف:
The presence of bone metastases in patients with metastatic renal cell carcinoma treated with oral tyrosine kinase inhibitors (TKIs) is associated with poorer outcome as compared with patients without bone involvement. Concomitant bisphosphonates could probably improve outcomes but also induce osteonecrosis of the jaw (ONJ).
وصف الملف:
1 full-text file(s): application/pdf
تدمد:
1532-1827
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb22c4137af4f142fa2a48d0882b042Test https://pubmed.ncbi.nlm.nih.gov/23132391Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....cdb22c4137af4f142fa2a48d0882b042
قاعدة البيانات:
OpenAIRE
