Comparative clinical outcomes of insulin degludec and insulin glargine 300 U/mL after switching from other basal insulins in real‐world patients with type 1 and type 2 diabetes
| العنوان: | Comparative clinical outcomes of insulin degludec and insulin glargine 300 U/mL after switching from other basal insulins in real‐world patients with type 1 and type 2 diabetes |
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| المؤلفون: | Yukiko Hasegawa, Tetsuya Babazono, Junko Oya, Aki Katamine, Tomoko Nakagami, Yuichiro Kondo |
| المصدر: | Journal of Diabetes Investigation, Vol 12, Iss 11, Pp 1983-1991 (2021) Journal of Diabetes Investigation |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Insulin degludec, Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulins, Insulin Glargine, Type 2 diabetes, 030204 cardiovascular system & hematology, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Japan, Drug Substitution, Insulin glargine 300 U/mL, General Medicine, Articles, Middle Aged, Insulin, Long-Acting, Treatment Outcome, Clinical Science and Care, Female, Original Article, medicine.drug, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Real‐world clinical setting, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Aged, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, Insulin glargine, business.industry, Insulin, medicine.disease, RC648-665, Endocrinology, Diabetes Mellitus, Type 1, Logistic Models, Basal (medicine), chemistry, Diabetes Mellitus, Type 2, Glycated hemoglobin, business |
| الوصف: | Aims/Introduction To evaluate and compare the efficacy of insulin degludec (IDeg) and insulin glargine 300 U/mL (Gla300) 6 months after switching from other basal insulins by assessing the changes in glycated hemoglobin (HbA1c), body mass index (BMI), and insulin doses in patients with type 1 and type 2 diabetes in a real‐world clinical setting. Materials and Methods A total of 307 patients with type 1 diabetes and 294 patients with type 2 diabetes with HbA1c >7.0% were studied. Adjusted mean changes in HbA1c, BMI, and insulin doses were compared between IDeg (IDeg group) and Gla300 (Gla300 group) switchers. Multivariable logistic regression analyses were carried out to examine whether the IDeg or Gla300 group was associated with HbA1c or insulin dose reduction and BMI gain. Results HbA1c was significantly decreased in both the IDeg and Gla300 groups. Adjusted mean changes in HbA1c (approximately −0.3% and −0.5% in type 1 diabetes and type 2 diabetes patients, respectively) and BMI were similar between both groups. The mean change in insulin dose was slightly larger for dose reduction in the IDeg group than in the Gla300 group. Multivariable logistic regression models showed that the IDeg group was significantly associated with insulin dose reduction after adjusting for basal insulin type, insulin dose, and number of basal insulin injections at baseline and other confounding factors. Conclusions The current study suggested that IDeg and Gla300 have similar effects in reducing HbA1c and gaining BMI after switching from other basal insulins in Japanese patients with type 1 diabetes and type 2 diabetes. IDeg selection was associated with insulin dose reduction. Insulin degludec and insulin glargine 300 U/mL showed similar values of reduction in glycated hemoglobin with body mass index almost unchanged 6 months after switching from other basal insulins in both type 1 and type 2 diabetes patients. Switching to insulin degludec was significantly associated with a reduction of basal and total insulin doses in both type 1 and type 2 diabetes patients. |
| اللغة: | English |
| تدمد: | 2040-1116 2040-1124 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8e343952d329f98d4b6977a3a8fce5Test https://doaj.org/article/33e2f17798204034beea375b21f2d506Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cd8e343952d329f98d4b6977a3a8fce5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401116 20401124 |
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