High Levels of Chronic Immune Activation in the T-Cell Compartments of Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus Type 1 and on Highly Active Antiretroviral Therapy Are Reverted by Alpha Interferon and Ribavirin Treatment
| العنوان: | High Levels of Chronic Immune Activation in the T-Cell Compartments of Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus Type 1 and on Highly Active Antiretroviral Therapy Are Reverted by Alpha Interferon and Ribavirin Treatment |
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| المؤلفون: | Veronica D. Gonzalez, Alex Lund Laursen, Karolin Falconer, Nina Weis, Johan K. Sandberg, Annette Alaeus, Kim Blom, Birgitte Mørn, Olle Reichard |
| المصدر: | BASE-Bielefeld Academic Search Engine |
| بيانات النشر: | American Society for Microbiology, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, T-Lymphocytes, T cell, Hepatitis C virus, Immunology, Alpha interferon, HIV Infections, Hepacivirus, Biology, Lymphocyte Activation, medicine.disease_cause, Antiviral Agents, Microbiology, Virus, Young Adult, T-Lymphocyte Subsets, Interferon, Antiretroviral Therapy, Highly Active, Virology, Ribavirin, medicine, Humans, Interferon alfa, Interferon-alpha, virus diseases, Hepatitis C, Chronic, Middle Aged, Viral Load, medicine.disease, ADP-ribosyl Cyclase 1, digestive system diseases, medicine.anatomical_structure, Insect Science, Disease Progression, HIV-1, Coinfection, Pathogenesis and Immunity, Female, Viral load, medicine.drug |
| الوصف: | Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients. |
| تدمد: | 1098-5514 0022-538X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7aceb0b1c29eac84c07b2e7647feaeTest https://doi.org/10.1128/jvi.01211-09Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cd7aceb0b1c29eac84c07b2e7647feae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985514 0022538X |
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