Impact of lockdown COVID-19 on metabolic control in type 2 diabetes mellitus and healthy people
| العنوان: | Impact of lockdown COVID-19 on metabolic control in type 2 diabetes mellitus and healthy people |
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| المؤلفون: | Tijen Yesim, Selvihan Beysel, Savas Karatas |
| المصدر: | Primary Care Diabetes |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, Male, Turkey, BMI, body mass index, COVİD-19 lockdown, Endocrinology, Diabetes and Metabolism, Metabolic disorders, Comorbidity, Type 2 diabetes, Body Mass Index, 0302 clinical medicine, WC, waist circumference, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Original Research, Nutrition and Dietetics, TG, triglyceride, Diabetes, Middle Aged, COVID-19, Coronavirus Disease 2019, Quarantine, Female, medicine.symptom, Family Practice, medicine.medical_specialty, HbA1c, haemoglobin A1c, 030209 endocrinology & metabolism, HDL-C, high-density lipoprotein-cholesterol, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, LDL-C, low-density lipoprotein-cholesterol, FPG, fasting plasma glucose, Pandemics, Weight gain, Retrospective Studies, SARS-CoV-2, business.industry, COVID-19, Type 2 Diabetes Mellitus, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Metabolic control analysis, Communicable Disease Control, Blood sugar regulation, business, Body mass index |
| الوصف: | Highlights • Pandemic lockdowns have caused deterioration in diet and exercise, according to recent studies. • Diabetes patients and non-diabetes patients gained weight in the pandemic period. • HbA1c, blood glucose, and lipid levels were increased in diabetes patients. • No significant change in blood glucose levels of non-diabetes subjects was observed. • There was a nonsignificant decrease in LDL and TG levels of non-diabetes subjects. Aims The impact of prolonged COVID-19 lockdown on metabolic control in type 2 diabetes patients and healthy individuals has not exactly been known. We aimed to evaluate the change in body weight and metabolic control in type 2 diabetic and non-diabetic healthy subjects during the prolonged lockdown period. Methods Diabetic (n = 85), and age-and sex-matched non-diabetic subjects (n = 55) were included in this prospective study. Body mass index and metabolic parameters were compared between before and 6th months of lockdown. Changes in values were evaluated using the difference before and after lockdown. Results Age (54.81 ± 10.53 vs. 52.61 ± 4.88 years), gender (female, 68.2% vs. 56.4%) and, BMI (33.44 ± 6.48 vs. 31.63 ± 3.57 kg/m2) were similar between groups (p > 0.05). Before and after lockdown, BMI increased both in non-diabetic (0.54 ± 0.95 kg) and diabetic groups (1.91 ± 5.48 kg) (p > 0.05). Increase in HbA1c was more in diabetic than in non-diabetic groups (0.71 ± 1.35 vs. 0.02 ± 0.19%, p = 0.002). Glucose, LDL-C, and TG increased in diabetic (39.69 ± 74.69, 7.60 ± 34.33, and 58.21 ± 133.54 mg/dl, p < 0.05) whereas non significantly decreased in non-diabetic group (−0.51 ± 4.40, −3.52 ± 14.53, and −6.47 ± 41.77 mg/dl, respectively. After adjusting BMI, increase in blood glucose (p = 0.021), HbA1c (p = 0.018), and TG (p = 0.041) levels were more in diabetic than non-diabetic group. Duration of diabetes was an independent predictor of the change in HbA1c (OR: 1.2, 95% CI = 1.1–1.8, p = 0.032). Conclusions Body weight gain was observed in type 2 diabetic patients and healthy subjects. This is the first study to show that prolonged lockdown COVID-19 pandemic worsened glucose regulation and increased TG level in diabetes mellitus independent of weight gain. |
| تدمد: | 1751-9918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd097d807954478fe97170130db24d82Test https://doi.org/10.1016/j.pcd.2021.01.003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cd097d807954478fe97170130db24d82 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17519918 |
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