Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia
| العنوان: | Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia |
|---|---|
| المؤلفون: | Jiahui Zhang, Jinfeng Wu, Wei Ji, Yongdong Yan, Zhichao Sun, Li Huang, Zhengrong Chen, Rongrong Li, Ting Wang, Jiahong Tan |
| المصدر: | BMC Infectious Diseases BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | Research Square Platform LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Mycoplasma pneumoniae, Neutrophils, Mucus plug, medicine.disease_cause, Gastroenterology, 0302 clinical medicine, Adrenal Cortex Hormones, Risk Factors, Prealbumin, 030212 general & internal medicine, Child, Children, Univariate analysis, Infectious Diseases, C-Reactive Protein, Child, Preschool, Female, medicine.symptom, Research Article, medicine.medical_specialty, Mycoplasma pneumoniae pneumonia, Fever, Bronchial mucus, Bronchi, lcsh:Infectious and parasitic diseases, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, 030225 pediatrics, Internal medicine, Bronchoscopy, Pneumonia, Mycoplasma, medicine, Humans, lcsh:RC109-216, Risk factor, Retrospective Studies, L-Lactate Dehydrogenase, business.industry, Infant, Odds ratio, Length of Stay, medicine.disease, Mucus, Pneumonia, Logistic Models, ROC Curve, Sputum, business |
| الوصف: | Background Recently, many cases of pneumonia in children with Mycoplasma pneumoniae infection have been shown to have varying degrees of intrabronchial mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of patients with Mycoplasma infection are analyzed in this study. The risk factors for M. pneumoniae pneumonia (MPP) mucus plug formation in children are explored, and a risk factor scoring system is established. Methods MPP patients treated with bronchoscopy were retrospectively enrolled in the study from February 2015 to December 2019. The children were divided into a mucus plug group and a control group according to the presence or absence of mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of the two groups of children were compared. Univariate and multivariate logistic regression models were used to identify the risk factors for MPP mucus plug formation. The receiver operating characteristic (ROC) curve was drawn to evaluate the regression model and establish the MPP mucous plug risk factor scoring system. Results A univariate analysis showed that the children in the mucous group were older and had a longer fever duration, longer hospital stay, higher fever peak, more cases of wheezing symptoms and allergies, and azithromycin or corticosteroids were administered later. In addition, neutrophil, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), sputum MP-DNA copy number, and total immunoglobulin A (IgA) levels were higher, while prealbumin (PA) levels were lower. The ROC curve analysis showed that children with MPP had PA ≤144.5 mg/L, had used corticosteroids during the course of the illness of ≥4.5 days, CRP ≥12.27 mg/L, an LDH ≥ 462.65 U/L, and there was a possibility of intra-airway mucus formation. The independent risk factors were scored according to their odds ratio (OR) value. Among the 255 children with MPP, the high-risk group had 44 (83.02%) mucus plugs out of 53; the middle-risk group had 35 (34.3%) mucus plugs out of 102; and the low-risk group had 11 (11%) mucus plugs out of 100. Conclusions PA levels, timing of corticosteroid use (use in the first few days), CRP levels, and LDH levels were independent risk factors for MPP mucus plug formation. This provides a basis for the early identification of MPP in children combined with mucus plug formation. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd21c1410001c4467a4bd7df9fa246cTest https://doi.org/10.21203/rs.3.rs-54708/v3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ccd21c1410001c4467a4bd7df9fa246c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |