The Effects of External Heating on the Permeation of Oxybutynin through Human Epidermal Membrane
| العنوان: | The Effects of External Heating on the Permeation of Oxybutynin through Human Epidermal Membrane |
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| المؤلفون: | Haruhi Mizushima, Hitoshi Ishizuka, Kazuhiro Inoue |
| المصدر: | Biological and Pharmaceutical Bulletin. 30:612-615 |
| بيانات النشر: | Pharmaceutical Society of Japan, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Time Factors, Skin Absorption, Pharmaceutical Science, Muscarinic Antagonists, In Vitro Techniques, Isosorbide Dinitrate, Administration, Cutaneous, Heating, Drug Delivery Systems, Electricity, Pharmacokinetics, Cadaver, medicine, Humans, Oxybutynin, Diffusion cell, Transdermal, Pharmacology, Chromatography, Chemistry, Temperature, Stereoisomerism, General Medicine, Permeation, Membrane, Solubility, Mandelic Acids, Thermodynamics, Delivery system, Epidermis, Isosorbide dinitrate, Algorithms, medicine.drug |
| الوصف: | The transdermal delivery system (TDS) of oxybutynin (OXY) is widely used for the treatment of overactive bladder patients. This report aimed to assess the effect of external heating on the pharmacokinetics of OXY after transdermal administration. Franz-type diffusion cell experiments at room temperature, 36 and 45 degrees C were performed to estimate the permeations of OXY through human epidermal membrane with an isosorbide dinitrate (ISDN) formulation as a reference. The fluxes of OXY at 36 and 45 degrees C were only approximately 1.2-fold higher than that at room temperature, while those of ISDN with heating were more than 2.5 times as high as that without heating (p0.001). These results indicate that the influence of heating on the permeation of OXY from the TDS of OXY may be minimal. |
| تدمد: | 1347-5215 0918-6158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccd71d269074def599854beb94c0121Test https://doi.org/10.1248/bpb.30.612Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cccd71d269074def599854beb94c0121 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475215 09186158 |
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