Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy
| العنوان: | Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy |
|---|---|
| المؤلفون: | Hanna Skärstrand, Lars B. Dahlin, Fariba Vaziri-Sani, Åke Lernmark |
| المصدر: | Journal of Diabetes and its Complications; Vol 27 Journal of Diabetes and its Complications; 27(6), pp 609-617 (2013) |
| بيانات النشر: | Elsevier, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, endocrine system, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Endocrinology and Diabetes, medicine.disease_cause, Autoimmunity, Pathogenesis, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Diabetic Neuropathies, Diabetes mellitus, Internal medicine, mental disorders, Internal Medicine, medicine, Humans, Neuropeptide Y, 030304 developmental biology, Aged, Autoantibodies, Aged, 80 and over, 0303 health sciences, Type 1 diabetes, business.industry, Autoantibody, nutritional and metabolic diseases, Middle Aged, medicine.disease, Neuropeptide Y receptor, humanities, 3. Good health, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Case-Control Studies, Female, Radiobinding assay, business |
| الوصف: | Aims: The neurotransmitter Neuropeptide Y (NPY) was previously reported as a minor autoantigen in newly diagnosed type 1 diabetes (T1D) patients. The single nucleotide polymorphism at rs16139 (T1128C, L7P) in the NPY gene was associated with an increased risk for the development of type 2 diabetes (T2D). We aimed to develop a radiobinding assay for NPY-L (Leucine) and NPY-P (Proline) autoantibodies (A) to study the levels and the association with other islet autoantibodies and neuropathy. Methods: Autoantibodies against NPY-L, NPY-P, ZnT8, GAD65 and IA-2 were studied in T1D (n=48) and T2D (n=26) patients with duration up to 42 and 31years. A subgroup of T1D (n=32) patients re-examined, 5-8years after first visit, was tested for peripheral (Z-score) and autonomic neuropathy (E/I ratio). Results: NPY-LA and NPY-PA were detected in 23% and 19% in T1D (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1056-8727 1873-460X |
| DOI: | 10.1016/j.jdiacomp.2013.06.007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc796ccbcb65403d2a133d1ffe1875ccTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cc796ccbcb65403d2a133d1ffe1875cc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10568727 1873460X |
|---|---|
| DOI: | 10.1016/j.jdiacomp.2013.06.007 |