Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer
| العنوان: | Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer |
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| المؤلفون: | Maria Simonsson, Ann H. Rosendahl, Christian Ingvar, Li Zeng, Claire M Perks, Jeffrey M P Holly, Andrea Markkula, Carsten Rose, Helena Jernström |
| المصدر: | Clinical Cancer Research. 21:1877-1887 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, Cell Survival, Population, Estrogen receptor, Breast Neoplasms, Coffea, Receptor, IGF Type 1, Young Adult, chemistry.chemical_compound, Caffeic Acids, Breast cancer, Risk Factors, Caffeine, Cell Line, Tumor, Internal medicine, Biomarkers, Tumor, Caffeic acid, medicine, Humans, Neoplasm Metastasis, education, Aged, Cell Proliferation, Aged, 80 and over, education.field_of_study, business.industry, Cell Cycle, Cancer, Middle Aged, medicine.disease, Tumor Burden, Endocrinology, Receptors, Estrogen, Oncology, chemistry, Hormone receptor, Female, Neoplasm Grading, Neoplasm Recurrence, Local, business, Tamoxifen, medicine.drug |
| الوصف: | Purpose: Epidemiologic studies indicate that dietary factors, such as coffee, may influence breast cancer and modulate hormone receptor status. The purpose of this translational study was to investigate how coffee may affect breast cancer growth in relation to estrogen receptor-α (ER) status. Experimental Design: The influence of coffee consumption on patient and tumor characteristics and disease-free survival was assessed in a population-based cohort of 1,090 patients with invasive primary breast cancer in Sweden. Cellular and molecular effects by the coffee constituents caffeine and caffeic acid were evaluated in ER+ (MCF-7) and ER− (MDA-MB-231) breast cancer cells. Results: Moderate (2–4 cups/day) to high (≥5 cups/day) coffee intake was associated with smaller invasive primary tumors (Ptrend = 0.013) and lower proportion of ER+ tumors (Ptrend = 0.018), compared with patients with low consumption (≤1 cup/day). Moderate to high consumption was associated with lower risk for breast cancer events in tamoxifen-treated patients with ER+ tumors (adjusted HR, 0.51; 95% confidence interval, 0.26–0.97). Caffeine and caffeic acid suppressed the growth of ER+ (P ≤ 0.01) and ER− (P ≤ 0.03) cells. Caffeine significantly reduced ER and cyclin D1 abundance in ER+ cells. Caffeine also reduced the insulin-like growth factor-I receptor (IGFIR) and pAkt levels in both ER+ and ER− cells. Together, these effects resulted in impaired cell-cycle progression and enhanced cell death. Conclusions: The clinical and experimental findings demonstrate various anticancer properties of caffeine and caffeic acid against both ER+ and ER− breast cancer that may sensitize tumor cells to tamoxifen and reduce breast cancer growth. Clin Cancer Res; 21(8); 1877–87. ©2015 AACR. |
| تدمد: | 1557-3265 1078-0432 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf8c09abf9f33988899ad55eee957c8Test https://doi.org/10.1158/1078-0432.ccr-14-1748Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cbf8c09abf9f33988899ad55eee957c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573265 10780432 |
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