Insulin micro-secretion in Type 1 diabetes and related microRNA profiles
| العنوان: | Insulin micro-secretion in Type 1 diabetes and related microRNA profiles |
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| المؤلفون: | Anthony C Keech, Yoon Hi Cho, Ryan J. Farr, Emma S. Scott, David N O'Neal, Anandwardhan A. Hardikar, Paul Z. Benitez-Aguirre, Mugdha V. Joglekar, Andrzej S. Januszewski, Luke M. Carroll, Alicia J. Jenkins, Maria E. Craig, Yik Wen Loh, Wilson K. M. Wong, Kim C. Donaghue |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, Male, 0301 basic medicine, Diabetes duration, medicine.medical_treatment, Autoimmunity, 0302 clinical medicine, Insulin-Secreting Cells, Insulin Secretion, Medicine, Child, Aged, 80 and over, Multidisciplinary, C-Peptide, Age Factors, Middle Aged, Type 1 diabetes, Female, Adult, medicine.medical_specialty, Adolescent, Science, 030209 endocrinology & metabolism, Article, Young Adult, 03 medical and health sciences, Diabetes mellitus, Internal medicine, microRNA, Humans, Secretion, Circulating MicroRNA, Insulin secretion, Aged, Autoantibodies, Glycated Hemoglobin, business.industry, Insulin, medicine.disease, MicroRNAs, Diabetes Mellitus, Type 1, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Genetic markers, Age of onset, business, Biomarkers |
| الوصف: | The aim of this cross-sectional study was to compare plasma C-peptide presence and levels in people without diabetes (CON) and with Type 1 diabetes and relate C-peptide status to clinical factors. In a subset we evaluated 50 microRNAs (miRs) previously implicated in beta-cell death and associations with clinical status and C-peptide levels. Diabetes age of onset was stratified as adult (≥ 18 y.o) or childhood ( 20 years. Plasma C-peptide was measured by ultrasensitive ELISA. Plasma miRs were quantified using TaqMan probe-primer mix on an OpenArray platform. C-peptide was detectable in 55.3% of (n = 349) people with diabetes, including 64.1% of adults and 34.0% of youth with diabetes, p p p = 0.02, respectively]. In the childhood-onset group more people with longer diabetes duration (> 20 years) had detectable C-peptide (60%) than in those with shorter diabetes duration (39%, p for trend |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd5b712c5082c4c879f559920494d80Test https://doaj.org/article/b1ec56fdb12a4c0cb5cb32be78d2f006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cbd5b712c5082c4c879f559920494d80 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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