rTMS modulates reciprocal inhibition in patients with traumatic spinal cord injury
| العنوان: | rTMS modulates reciprocal inhibition in patients with traumatic spinal cord injury |
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| المؤلفون: | Yvonne Höller, Peter Höller, Stefan Golaszewski, Andrea Orioli, Eugen Trinka, Aljoscha Thomschewski, Francesco Brigo, Raffaele Nardone |
| المصدر: | Spinal Cord. 52:831-835 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, Stress Disorders, Traumatic, Modified Ashworth scale, medicine.medical_treatment, Electromyography, H-Reflex, Double-Blind Method, medicine, Humans, Spasticity, Muscle, Skeletal, Spinal cord injury, Aged, Motor Neurons, Cross-Over Studies, Trauma Severity Indices, medicine.diagnostic_test, business.industry, musculoskeletal, neural, and ocular physiology, Motor Cortex, Reciprocal inhibition, Neural Inhibition, General Medicine, Middle Aged, Evoked Potentials, Motor, medicine.disease, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, medicine.anatomical_structure, nervous system, Neurology, Muscle Spasticity, Anesthesia, Female, Neurology (clinical), Primary motor cortex, medicine.symptom, business, Motor cortex |
| الوصف: | Randomized, double-blind, crossover, sham-controlled trial. Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) leads to a significant reduction of spasticity in subjects with spinal cord injury (SCI), but the physiological basis of this effect is still not well understood. The purpose of this study was to evaluate the disynaptic reciprocal Ia inhibition of soleus motoneurons in SCI patients. Department of Neurology, Merano, Italy and TMS Laboratory, Paracelsus Medical University, Salzburg, Austria. Nine subjects with incomplete cervical or thoracic SCI received 5 days of daily sessions of real or sham rTMS applied over the contralateral M1. We compared the reciprocal inhibition, the Modified Ashworth Scale and the Spinal Cord Injury Assessment Tool for Spasticity at baseline, after the last session and 1 week later in the real rTMS and sham stimulation groups. We found that real rTMS significantly reduced lower limb spasticity and restored the impaired excitability in the disynaptic reciprocal inhibitory pathway. In a small proof-of-concept study, rTMS strengthened descending projections between the motor cortex and inhibitory spinal interneuronal circuits. This reversed a defect in reciprocal inhibition after SCI, and reduced leg spasticity. |
| تدمد: | 1476-5624 1362-4393 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc214f6c0ff2d44bd601a0b5ff499ebTest https://doi.org/10.1038/sc.2014.136Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cbc214f6c0ff2d44bd601a0b5ff499eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765624 13624393 |
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