NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?
| العنوان: | NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination? |
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| المؤلفون: | Gutian Xiao |
| المصدر: | Retrovirology, Vol 9, Iss 1, p 78 (2012) Retrovirology |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, Viral protein, Tax, SUMO protein, IκB kinase, medicine.disease_cause, Models, Biological, NF-κB, Nuclear body, 03 medical and health sciences, chemistry.chemical_compound, Ubiquitin, Virology, medicine, Humans, Transcription factor, Tumroigenesis, health care economics and organizations, 030304 developmental biology, Genetics, Human T-lymphotropic virus 1, 0303 health sciences, Leukemia, Retrovirus, biology, IKK, 030302 biochemistry & molecular biology, NF-kappa B, Ubiquitination, Sumoylation, Taxisome, Gene Products, tax, HTLV, NFKB1, biology.organism_classification, 3. Good health, Cell biology, Viewpoints, Infectious Diseases, chemistry, ATL, SUMO, Host-Pathogen Interactions, biology.protein, lcsh:RC581-607 |
| الوصف: | Activation of the NF-κB transcription factors by the viral protein Tax plays a vital role in the pathogenesis of diseases associated with human T-cell lymphotropic virus type I (HTLV-I). The Tax oncoprotein undergoes constitutive K63-linked ubiquitination and sumoylation; however, the roles and molecular mechanisms of these post-translational modifications in Tax-mediated NF-κB activation are being debated. Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing. |
| اللغة: | English |
| تدمد: | 1742-4690 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb89c9bcbd56582370a22c8c5e79ecbbTest http://www.retrovirology.com/content/9/1/78Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb89c9bcbd56582370a22c8c5e79ecbb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17424690 |
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