MRI features of low-grade and high-grade chondrosarcoma in enchondromatosis
| العنوان: | MRI features of low-grade and high-grade chondrosarcoma in enchondromatosis |
|---|---|
| المؤلفون: | Asif Saifuddin, Shahab Sharifi, Ramanan Rajakulasingam, Paul O'Donnell, Ban Sharif |
| المصدر: | Skeletal Radiology. 50:1637-1646 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Chondrosarcoma, Periosteal reaction, Bone Neoplasms, 030218 nuclear medicine & medical imaging, law.invention, Intramedullary rod, Young Adult, 03 medical and health sciences, 0302 clinical medicine, law, Biopsy, Enchondromatosis, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Child, Ollier disease, Aged, Aged, 80 and over, 030203 arthritis & rheumatology, medicine.diagnostic_test, business.industry, Soft tissue, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Female, Radiology, business, Chondroma |
| الوصف: | To identify magnetic resonance imaging (MRI) features which aid differentiation of low-grade chondral tumours (LGCT-enchondroma and grade 1 chondrosarcoma) from high-grade chondral tumours (HGCT) in patients with enchondromatosis. Approval from our local Research and Innovation Centre of The Institute of Orthopaedics was gained. Patients with enchondromatosis who had biopsy and/or resection of chondral lesions over a 13-year period were identified. The pre-biopsy MRI study was assessed by two experienced musculoskeletal radiologists for tumour origin (intramedullary or surface), cortical expansion, cortical destruction, bone marrow oedema, periosteal reaction, soft tissue mass and soft tissue oedema. MRI features were compared with the final histopathological diagnosis. The study group comprised 25 males and 16 females, with a mean age of 34.9 years (range 6–81 years). Fifty-nine lesions were assessed (12 patients had > 1 tumour treated), including 43 LGCT and 16 HGCT. Significant MRI features suggesting malignant transformation to HGCT for both observers included bone oedema (p = < 0.001 and 0.002), periosteal reaction (p = 0.01) and soft tissue oedema (p = 0.001 and 0.05). Cortical destruction and soft tissue mass were predictors of HGCT in major long bones, but no significant differentiating features were identified in the hands and feet. The presence of bone oedema, periosteal reaction and soft tissue oedema on MRI may indicate a high-grade malignant transformation of chondral tumours in patients with enchondromatosis. |
| تدمد: | 1432-2161 0364-2348 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7f8eca4ecc56e9f13acde5c3f81f7eTest https://doi.org/10.1007/s00256-021-03718-7Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....cb7f8eca4ecc56e9f13acde5c3f81f7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322161 03642348 |
|---|