High serum levels of YKL‐40 in patients with systemic sclerosis are associated with pulmonary involvement
| العنوان: | High serum levels of YKL‐40 in patients with systemic sclerosis are associated with pulmonary involvement |
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| المؤلفون: | Paul A. Price, Poul Halberg, Julia S. Johansen, Allan Wiik, C. Garbarsch, C. Nordenbæk, S Ullman, Søren Jacobsen |
| المصدر: | Scandinavian Journal of Rheumatology. 34:293-297 |
| بيانات النشر: | Informa UK Limited, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Systemic disease, Pathology, Pulmonary Fibrosis, Severity of Illness Index, Cohort Studies, Reference Values, DLCO, Fibrosis, Lectins, Diffusing capacity, Pulmonary fibrosis, Immunology and Allergy, Aged, 80 and over, integumentary system, medicine.diagnostic_test, Respiratory disease, Age Factors, General Medicine, Middle Aged, Prognosis, Connective tissue disease, Respiratory Function Tests, Disease Progression, Female, Adult, musculoskeletal diseases, medicine.medical_specialty, Immunology, Risk Assessment, Sensitivity and Specificity, Statistics, Nonparametric, Sex Factors, Adipokines, Rheumatology, Biopsy, medicine, Humans, Chitinase-3-Like Protein 1, Aged, Glycoproteins, Probability, Proportional Hazards Models, Scleroderma, Systemic, business.industry, medicine.disease, Survival Analysis, Case-Control Studies, business, Biomarkers |
| الوصف: | YKL-40, a growth factor of connective tissue cells, is elevated in sera from patients with diseases characterized by inflammation, tissue remodelling, or fibrosis. The aim of the study was to determine serum YKL-40 levels in patients with systemic sclerosis (SSc) and to explore any possible clinical and prognostic associations.YKL-40 was measured in sera from 88 patients with SSc (26 with diffuse and 62 with limited skin involvement) and in sera from 88 matched healthy controls. Immunohistochemical staining for YKL-40 antigen was performed in a biopsy from a patient with pulmonary SSc.Serum YKL-40 levels of the SSc patients were significantly higher than those of the controls (p0.00001). Patients with pulmonary fibrosis by chest X-ray, obstructive ventilatory pattern, reduced diffusing capacity (DLco), and digital joint deformity due to skin retraction had significantly higher serum YKL-40 compared with patients without these findings. Patients with elevated serum YKL-40 had shorter survival times than patients with normal serum YKL-40 (p = 0.0005), although this was not independent of age and pulmonary function. YKL-40 protein expression was found in inflammatory cells in fibrosing pulmonary tissue from a patient with SSc.Serum YKL-40 is elevated in patients with SSc with pulmonary involvement. |
| تدمد: | 1502-7732 0300-9742 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7befde770a65fcc9242127ec23ede6Test https://doi.org/10.1080/03009740510018598Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb7befde770a65fcc9242127ec23ede6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15027732 03009742 |
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