Plantar involvement correlates with obesity, pain and impaired mobility in epidermolysis bullosa simplex: a retrospective cohort study
| العنوان: | Plantar involvement correlates with obesity, pain and impaired mobility in epidermolysis bullosa simplex: a retrospective cohort study |
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| المؤلفون: | Moritz Hess, Leena Bruckner-Tuderman, Cristina Has, Antonia Reimer-Taschenbrecker, Alrun Hotz, Judith Fischer |
| المصدر: | Journal of the European Academy of Dermatology and Venereology. 35:2097-2104 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Pain, Dermatology, Overweight, 030207 dermatology & venereal diseases, 03 medical and health sciences, Epidermolysis bullosa simplex, 0302 clinical medicine, medicine, Humans, Obesity, Keratoderma, Disease burden, Retrospective Studies, business.industry, Genodermatosis, Retrospective cohort study, medicine.disease, Infectious Diseases, Child, Preschool, Epidermolysis Bullosa Simplex, Epidermolysis bullosa, medicine.symptom, Epidermolysis Bullosa, business, Body mass index, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Background Epidermolysis bullosa simplex (EBS) is the most common type of EB, a group of rare genodermatoses. Affected individuals suffer from skin blistering and report a high disease burden. In some EBS subtypes, plantar keratoderma (PK) has been described. Objectives This study investigated the presence and correlation of PK with body mass index, pain and mobility in EBS. Methods Individuals (n = 157) with genetically characterized EBS were included in this retrospective cohort study, and clinical data were collected over 16 years (referral patients to the largest German EB centre). Descriptive statistics and mixed linear models were used to assess correlations. Results PK was found in 75.8% of patients beginning at a mean age of 4.3 years. Both focal and diffuse PK were observed, and 60% of adults with localized and severe EBS were preobese or obese, with ˜30% of patients reporting severely reduced mobility. The presence of PK, especially diffuse PK, correlated significantly with local infections, obesity, pain and requirement of a wheelchair. Conclusion Along with treating skin fragility and blistering, PK should be considered a potential marker of increased morbidity and may represent a target of EBS therapy development. |
| تدمد: | 1468-3083 0926-9959 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb582c197a5185d80a06c0f1e8bc0289Test https://doi.org/10.1111/jdv.17336Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb582c197a5185d80a06c0f1e8bc0289 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683083 09269959 |
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