Quantitative roles of ion channel dynamics on ventricular action potential
| العنوان: | Quantitative roles of ion channel dynamics on ventricular action potential |
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| المؤلفون: | Sevgi Şengül Ayan, Ahmet Kürşad Sırcan |
| المساهمون: | Şengül Ayan, Sevgi, 236492 [Şengül Ayan, Sevgi], 57216946397 [Şengül Ayan, Sevgi] |
| المصدر: | Channels article-version (VoR) Version of Record |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Work (thermodynamics), Heart Ventricles, Biophysics, Phase (waves), Action Potentials, Voltaj kapılı iyon kanalları, contribution analysis, Biochemistry, Measure (mathematics), Ion Channels, Ventricular action potential, Contribution analysis, İyonik akımların dinamiği, Quantitative analysis, Ion channel, Physics, quantitative analysis, Voltage-gated ion channel, Mathematical model, dynamics of ionic currents, ventricular action potential, Nicel analiz, Dynamics of ionic currents, Nonlinear system, Ventriküler aksiyon potansiyeli, Katkı analizi, Voltage-gated ion channels, Biological system, Ion Channel Gating, Research Article, Research Paper |
| الوصف: | Mathematical models for the action potential (AP) generation of the electrically excitable cells including the heart are involved different mechanisms including the voltage-dependent currents with nonlinear time- and voltage-gating properties. From the shape of the AP waveforms to the duration of the refractory periods or heart rhythms are greatly affected by the functions describing the features or the quantities of these ion channels. In this work, a mathematical measure to analyze the regional contributions of voltage-gated channels is defined by dividing the AP into phases, epochs, and intervals of interest. The contribution of each time-dependent current for the newly defined cardiomyocyte model is successfully calculated and it is found that the contribution of dominant ion channels changes substantially not only for each phase but also for different regions of the cardiac AP. Besides, the defined method can also be applied in all Hodgkin–Huxley types of electrically excitable cell models to be able to understand the underlying dynamics better. No sponsor |
| وصف الملف: | application/pdf |
| تدمد: | 1933-6969 1933-6950 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb470bb577786cc39a463d6052427014Test https://doi.org/10.1080/19336950.2021.1940628Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb470bb577786cc39a463d6052427014 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19336969 19336950 |
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