Reintroduction failure after negative food challenges in adults is common and mainly due to atypical symptoms
| العنوان: | Reintroduction failure after negative food challenges in adults is common and mainly due to atypical symptoms |
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| المؤلفون: | André C. Knulst, Harmieke van Os-Medendorp, Astrid Versluis, Yolanda Meijer, Francine C. van Erp, Mark A. Blankestijn, Thuy-My Le |
| المصدر: | Clinical and Experimental Allergy |
| بيانات النشر: | John Wiley and Sons Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Adolescent, Immunology, Aftercare, Anxiety, Culprit, food challenge, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Food allergy, Internal medicine, Surveys and Questionnaires, medicine, Immunology and Allergy, Humans, Clinical significance, Prospective Studies, Prospective cohort study, Clinical Allergy, reintroduction, Aged, Univariate analysis, food allergy, business.industry, Feeding Behavior, Middle Aged, medicine.disease, 030104 developmental biology, 030228 respiratory system, Telephone interview, Food, Quality of Life, Original Article, Female, medicine.symptom, ORIGINAL ARTICLES, business, Food Hypersensitivity |
| الوصف: | BACKGROUND: Reintroduction of a food after negative food challenge (FC) faces many obstacles. There are no studies available about this subject in adults. OBJECTIVE: To investigate the frequency, reasons and risk factors of reintroduction failure in adults. METHODS: In this prospective study, adult patients received standardized follow-up care after negative FCs including a reintroduction scheme and supportive telephone consultations. Data were collected by telephone interview (2 weeks after FC) and questionnaires (at baseline and 6 months after FC(s)): food habits questionnaire, State-Trait Anxiety Inventory, Food Allergy Quality of Life Questionnaire-Adult Form and Food Allergy Independent Measure. Frequency and reasons of reintroduction failure were analysed using descriptive statistics and risk factors with univariate analyses. RESULTS: Eighty patients were included with, in total, 113 negative FCs. Reintroduction failed on short-term (2 weeks after FC) in 20% (95% CI: 13%-28%). Common reasons were symptoms upon ingestion during the reintroduction scheme (50%) and no need to eat the food (23%). On the long-term (5-12 months after FC(s)), reintroduction failure increased to 40% (95% CI: 28%-53%). Common reasons were atypical symptoms after eating the food (59%) and fear for an allergic reaction (24%). Five risk factors for long-term reintroduction failure were found: if culprit food was not one of the 13 EU regulated allergens, reintroduction failure at short-term, atypical symptoms during FC, a lower quality of life and a higher state anxiety. CONCLUSIONS AND CLINICAL RELEVANCE: Reintroduction failure after negative FCs in adults is common, increases over time, and is primarily due to atypical symptoms. This stresses the need for more patient-tailored care before and after negative food challenges. |
| اللغة: | English |
| تدمد: | 1365-2222 0954-7894 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacc1a980571149e2982eb65894f5233Test http://europepmc.org/articles/PMC7187472Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cacc1a980571149e2982eb65894f5233 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652222 09547894 |
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