Resolution of inflammation is altered in Alzheimer's disease
| العنوان: | Resolution of inflammation is altered in Alzheimer's disease |
|---|---|
| المؤلفون: | Charles N. Serhan, Jonathan M. Fitzgerald, Mingqin Zhu, Jan Palmblad, Caroline Graff, Kumar Sambamurti, Erik Hjorth, Xiuzhe Wang, Helga Eyjolfsdottir, Maria Eriksdotter, Veronica Cortés-Toro, Marianne Schultzberg, Inger Nennesmo, Ann-Charlotte Granholm |
| المصدر: | Alzheimer's & Dementia. 11:40 |
| بيانات النشر: | Wiley, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Docosahexaenoic Acids, Epidemiology, Lipoxygenase, Hippocampus, tau Proteins, Inflammation, Hippocampal formation, Biology, Article, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Cerebrospinal fluid, Developmental Neuroscience, Alzheimer Disease, medicine, Humans, Cognitive Dysfunction, Receptors, Lipoxin, Receptor, Aged, Lipoxin, Amyloid beta-Peptides, Health Policy, Human brain, Middle Aged, medicine.disease, Receptors, Formyl Peptide, Lipoxins, Psychiatry and Mental health, medicine.anatomical_structure, chemistry, Case-Control Studies, Immunology, Female, Neurology (clinical), Inflammation Mediators, Geriatrics and Gerontology, Alzheimer's disease, medicine.symptom, Biomarkers |
| الوصف: | Background Resolution is the final stage of the inflammatory response, when restoration of tissue occurs. Failure may lead to chronic inflammation, which is known as part of the pathology in the brain of individuals with Alzheimer's disease (AD). Methods Specialized pro-resolving mediators (SPMs), receptors, biosynthetic enzyme, and downstream effectors involved in resolution were analyzed in postmortem hippocampal tissue from AD patients and non-AD subjects. SPMs were analyzed in cerebrospinal fluid (CSF). Results SPMs and SPM receptors were detected in the human brain. Levels of the SPM lipoxin A 4 (LXA 4 ) were reduced in AD, both in the CSF and hippocampus. An enzyme involved in LXA 4 synthesis and two SPM receptors were elevated in AD brains. LXA 4 and RvD1 levels in CSF correlated with Mini-Mental State Examination (MMSE) scores. Conclusions A resolution pathway exists in the brain and the alterations described herein strongly suggest a dysfunction of this pathway in AD. MMSE correlations suggest a connection with cognitive function in AD. |
| تدمد: | 1552-5279 1552-5260 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabc32f20a6ec9bd8465defa459b81dcTest https://doi.org/10.1016/j.jalz.2013.12.024Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cabc32f20a6ec9bd8465defa459b81dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525279 15525260 |
|---|