Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms
| العنوان: | Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms |
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| المؤلفون: | Sofia Ferreira, Natasa Loncarevic-Vasiljkovic, Sara Mota, Carolina Lage Crespo, Regina Menezes, Beatriz Alves-Dias, Diogo Carregosa, Cláudia N. Santos, Rita O. Teodoro |
| المصدر: | Nutrients, Vol 13, Iss 2940, p 2940 (2021) Nutrients |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Saccharomyces cerevisiae, ved/biology.organism_classification_rank.species, Context (language use), Review, Biology, Gut flora, Caenorhabditis elegans, 03 medical and health sciences, 0302 clinical medicine, medicine, microbiota, Humans, TX341-641, human, Cognitive decline, Model organism, Beneficial effects, Economic consequences, Aged, 030304 developmental biology, 0303 health sciences, Nutrition and Dietetics, Catabolism, ved/biology, Nutrition. Foods and food supply, Neurodegeneration, neurodegeneration, Polyphenols, Neurodegenerative Diseases, medicine.disease, biology.organism_classification, phytochemicals, zebrafish, Diet, Gastrointestinal Microbiome, 3. Good health, Drosophila, Biochemistry, rodents, 030217 neurology & neurosurgery, Food Science |
| الوصف: | The rise of neurodegenerative diseases in an aging population is an increasing problem of health, social and economic consequences. Epidemiological and intervention studies have demonstrated that diets rich in (poly)phenols can have potent health benefits on cognitive decline and neurodegenerative diseases. Meanwhile, the role of gut microbiota is ever more evident in modulating the catabolism of (poly)phenols to dozens of low molecular weight (poly)phenol metabolites that have been identified in plasma and urine. These metabolites can reach circulation in higher concentrations than parent (poly)phenols and persist for longer periods of time. However, studies addressing their potential brain effects are still lacking. In this review, we will discuss different model organisms that have been used to study how low molecular weight (poly)phenol metabolites affect neuronal related mechanisms gathering critical insight on their potential to tackle the major hallmarks of neurodegeneration. |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caae59bdaeb72f33f9109bd93de73818Test https://www.mdpi.com/2072-6643/13/9/2940Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....caae59bdaeb72f33f9109bd93de73818 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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