Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma
| العنوان: | Lymphatic invasion is a significant indicator of poor patient outcome in canine bladder urothelial carcinoma |
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| المؤلفون: | Veronica Mollica Govoni, Valeria Grieco, Carlos Eduardo Fonseca-Alves, Thayna Oliveira da Silva, Fernanda Zuliani, Juliany Gomes Quitzan, Renée Laufer-Amorim, Felipe Augusto Ruiz Sueiro, C. Pigoli |
| المساهمون: | Universidade Estadual Paulista (UNESP), Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna (IZSLER), University of Milan, VetPat Laboratory, Paulista University—UNIP |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Open Veterinary Journal, Vol 11, Iss 4, Pp 535-543 (2021) Open Veterinary Journal Open Veterinary Journal; Vol. 11 No. 4 (2021); 535–543 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Lymphovascular invasion, Urinary Bladder, Gastroenterology, chemistry.chemical_compound, Dogs, Transitional cell carcinoma, Internal medicine, transitional cell carcinoma, medicine, Lymphatic vessel, Dog, Animals, Humans, Dog Diseases, Survival analysis, Original Research, Carcinoma, Transitional Cell, Urinary bladder, General Veterinary, business.industry, Bladder cancer, Cancer, medicine.disease, Prognosis, Carboplatin, Vinblastine, medicine.anatomical_structure, chemistry, Urinary Bladder Neoplasms, QL1-991, dog, bladder cancer, Female, prognosis, business, Zoology, Brazil, medicine.drug |
| الوصف: | Made available in DSpace on 2022-04-29T08:37:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Background: Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common malignant tumor of the canine urinary bladder and represents a model for studying human bladder cancer. However, the existing literature has limited data on the clinicopathological characteristics of these tumors and their prognostic value. Aim: The aim of this study was to evaluate such factors, correlating them with follow-up, in a group of 32 dogs with bladder UC. Methods: Clinical data of these cases, submitted to São Paulo State University and VetPat Private Laboratory (São Paulo/Brazil), were recorded between January 2000 and November 2019. For each case, formalin-fixed and paraffinembedded sections were stained with hematoxylin and eosin and histologically evaluated. Survival analysis was carried out, and the prognostic value of the presence of lymphatic invasion and the treatment used was determined. Results: Dogs with neoplastic lymphatic vessel invasion had a lower overall survival compared to those without lymphatic invasion, and dogs that received vinblastine in addition to surgery had higher global survival when compared to animals that received carboplatin in addition to surgery. Conclusion: The results obtained show the importance of further studies regarding the prognostic value of the two factors demonstrated as potential survival predictors, especially the lymphatic vessel invasion. Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Sao Paulo State University—UNESP Laboratorio di Istologia Sede Territoriale di Milano Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna (IZSLER) Department of Veterinary Medicine University of Milan VetPat Laboratory Department of Veterinary Clinic School of Veterinary Medicine and Animal Science Sao Paulo State University— UNESP Institute of Health Sciences Paulista University—UNIP Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science Sao Paulo State University—UNESP Department of Veterinary Clinic School of Veterinary Medicine and Animal Science Sao Paulo State University— UNESP |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2218-6050 2226-4485 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fa4632aec9107badfac492f2ae995cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9fa4632aec9107badfac492f2ae995c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22186050 22264485 |
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