Aberrant DNA Methylation of Two Tumor Suppressor Genes, p14ARF and p15INK4b, after Chronic Occupational Exposure to Low Level of Benzene
| العنوان: | Aberrant DNA Methylation of Two Tumor Suppressor Genes, p14ARF and p15INK4b, after Chronic Occupational Exposure to Low Level of Benzene |
|---|---|
| المؤلفون: | Frouzandeh Mahjoubi, Iraj Jamebozorgi, Gholamreza Pouryagoub, Tayebeh Majidizadeh |
| المصدر: | The International Journal of Occupational and Environmental Medicine, Vol 9, Iss 3, Pp 145-151 (2018) The International Journal of Occupational and Environmental Medicine |
| بيانات النشر: | National Iranian Oil Company (NIOC) Health Organization, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Time Factors, tumor suppressor, 03 medical and health sciences, chemistry.chemical_compound, lcsh:RC963-969, 0302 clinical medicine, Tumor suppressor protein p14ARF, Occupational Exposure, Neoplasms, medicine, Humans, Epigenetics, Gene, Regulation of gene expression, DNA methylation, Dose-Response Relationship, Drug, business.industry, Public Health, Environmental and Occupational Health, Genes, tumor suppressor, Cancer, Benzene, Methylation, medicine.disease, Cyclin-dependent kinase inhibitor p15, Occupational Diseases, Leukemia, Cross-Sectional Studies, 030104 developmental biology, Genes, Gene Expression Regulation, chemistry, 030220 oncology & carcinogenesis, Chronic Disease, Cancer research, lcsh:Industrial medicine. Industrial hygiene, Original Article, business, DNA |
| الوصف: | Background: Exposure to benzene would be associated with many diseases including leukemia. Epigenetic alterations seem to be among the main mechanisms involved. Objective: To determine if chronic occupational exposure to low level of benzene would be associated with DNA methylation. Methods: Global DNA methylation and promoter-specific methylation of the two tumor suppressor genes, p14 ARF and p15 INK4b , were assessed employing methylation-specific PCR using the DNA extracted from 40 petrochemical workers exposed to ambient benzene levels of |
| اللغة: | English |
| تدمد: | 2008-6814 2008-6520 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b8e1c6151b454e862529a8d03fdbe7Test http://www.theijoem.com/ijoem/index.php/ijoem/article/view/1317Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9b8e1c6151b454e862529a8d03fdbe7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20086814 20086520 |
|---|