HER2 testing of gastro-oesophageal adenocarcinoma: a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee
| العنوان: | HER2 testing of gastro-oesophageal adenocarcinoma: a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee |
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| المؤلفون: | Richard J. Byers, Newton A C S Wong, Rachel Butler, Manuel Salto-Tellez, Mohammad Ilyas, Philippe Taniere, Fernanda Amary, Harry R Haynes, David Gonzalez |
| المصدر: | Wong, N A C S, Amary, F, Butler, R, Byers, R, Gonzalez, D, Haynes, H R, Ilyas, M, Salto-Tellez, M & Taniere, P 2018, ' HER2 testing of gastro-oesophageal adenocarcinoma : a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee ', Journal of Clinical Pathology, vol. 71, no. 5, pp. 388-394 . https://doi.org/10.1136/jclinpath-2017-204943Test |
| بيانات النشر: | BMJ, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Esophageal Neoplasms, Receptor, ErbB-2, Biopsy, Oesophageal adenocarcinoma, Antineoplastic Agents, Immunological, 0302 clinical medicine, Gastro, Trastuzumab, Molecular Targeted Therapy, Pathology, Molecular, Precision Medicine, skin and connective tissue diseases, Human Epidermal Growth Factor Receptor 2, Societies, Medical, Clinical Oncology, Pathology, Clinical, Clinical pathology, Molecular pathology, in-situ hybridisation, General Medicine, Immunohistochemistry, Molecular Diagnostic Techniques, 030220 oncology & carcinogenesis, immunohistochemistry, Adenocarcinoma, Esophagogastric Junction, guidance, medicine.drug, medicine.medical_specialty, Consensus, Clinical Decision-Making, Pathology and Forensic Medicine, 03 medical and health sciences, Predictive Value of Tests, Stomach Neoplasms, HER2, Biomarkers, Tumor, medicine, Humans, adenocarcinoma stomach, Medical physics, oesophagus, business.industry, Reproducibility of Results, medicine.disease, digestive system diseases, 030104 developmental biology, business |
| الوصف: | The use of biologics targeted to the human epidermal growth factor receptor 2 (HER2) protein is the latest addition to the armamentarium used to fight advanced gastric or gastro-oesophageal junction adenocarcinoma. The decision to treat with the biologic trastuzumab is completely dependent on HER2 testing of tumour tissue. In 2017, the College of American Pathologists, American Society for Clinical Pathology and the American Society of Clinical Oncology jointly published guidelines for HER2 testing and clinical decision making in gastro-oesophageal adenocarcinoma. The Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee has issued the following document as a commentary of these guidelines and, in parallel, to provide guidance on HER2 testing in National Health Service pathology departments within the UK. This guidance covers issues related to case selection, preanalytical aspects, analysis and interpretation of such HER2 testing. |
| وصف الملف: | application/pdf |
| تدمد: | 1472-4146 0021-9746 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c889757c4c2a29db116320e965b1f93cTest https://doi.org/10.1136/jclinpath-2017-204943Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c889757c4c2a29db116320e965b1f93c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14724146 00219746 |
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