Neurologic complications of intrathecal liposomal cytarabine administered prophylactically to patients with non-Hodgkin lymphoma
| العنوان: | Neurologic complications of intrathecal liposomal cytarabine administered prophylactically to patients with non-Hodgkin lymphoma |
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| المؤلفون: | Paula Rodriguez-Otero, Roberto Fernandez-Torron, Jaime Gállego Pérez-Larraya, Pablo Irimia, María Carmona-Iragui, Carlos Panizo, Eduardo Martínez-Vila, Jose-Alberto Palma |
| المصدر: | Journal of Neuro-Oncology. 103:603-609 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Antimetabolites, Antineoplastic, Cancer Research, medicine.medical_specialty, Neurology, medicine.medical_treatment, Internal medicine, medicine, Humans, Prospective cohort study, Injections, Spinal, Aged, Retrospective Studies, Chemotherapy, business.industry, Lymphoma, Non-Hodgkin, Ophthalmoscopes, Cytarabine, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Lymphoma, Conus medullaris, medicine.anatomical_structure, Oncology, Concomitant, Liposomes, Female, Neurology (clinical), Nervous System Diseases, Arachnoiditis, business, Follow-Up Studies |
| الوصف: | Central nervous system (CNS) prophylaxis is required during initial treatment of non-Hodgkin lymphoma (NHL) subtypes that carry a high risk of CNS involvement. Intrathecal (IT) liposomal cytarabine, a formulation with prolonged half-life, has been shown to be safe and effective in the treatment of meningeal disease in patients with high-grade lymphoma. We retrospectively reviewed all adult patients with high-grade NHL that received prophylactic therapy with IT liposomal cytarabine and developed neurologic complications in our institution between April 2007 and May 2009. We recorded information on hospital admission, chemotherapy regimens, clinical features, neuroimaging, cerebrospinal fluid, neurophysiology data, and outcome. Neurotoxicity was graded according to the National Cancer Institute Common Toxicity Criteria (NCI-CTC). Four of fourteen patients (28%) developed moderate or severe neurotoxicity (grades 2 and 3 of the NCI-CTC), manifested as conus medullaris/cauda equine syndrome or pseudotumour cerebri-like syndrome, after a median of 3.5 IT courses of liposomal cytarabine. All patients had received corticosteroids to prevent arachnoiditis. Liposomal cytarabine given via the IT route, even with concomitant corticosteroid administration, can result in significant neurotoxicity in some patients. We discuss the potential pathogenesis of these effects and suggest hypothetical therapeutic measures to prevent these complications. Specialists should be aware of these possible complications when administering prophylactic IT liposomal cytarabine in high-grade NHL patients, and additional prospective studies should be conducted to more clearly delineate the frequency and characteristics of these complications. |
| تدمد: | 1573-7373 0167-594X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8735420c59e75df6af6f02ce4444d14Test https://doi.org/10.1007/s11060-010-0428-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c8735420c59e75df6af6f02ce4444d14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737373 0167594X |
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