Association BetweenPlasminogen Activator Inhibitor-1-675 4G/5G Insertion/Deletion Polymorphism and Chronic Obstructive Pulmonary Disease
| العنوان: | Association BetweenPlasminogen Activator Inhibitor-1-675 4G/5G Insertion/Deletion Polymorphism and Chronic Obstructive Pulmonary Disease |
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| المؤلفون: | Enas S Essa, Rabab A. El Wahsh |
| المصدر: | COPD: Journal of Chronic Obstructive Pulmonary Disease. 13:756-759 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Genotype, Genes, Recessive, Disease, 030204 cardiovascular system & hematology, Gastroenterology, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, INDEL Mutation, Internal medicine, Plasminogen Activator Inhibitor 1, Humans, Medicine, Promoter Regions, Genetic, Aged, Genes, Dominant, COPD, Polymorphism, Genetic, business.industry, Smoking, Case-control study, Odds ratio, Middle Aged, medicine.disease, respiratory tract diseases, 030228 respiratory system, chemistry, Case-Control Studies, Plasminogen activator inhibitor-1, Sputum, medicine.symptom, business, Plasminogen activator |
| الوصف: | Molecular pathology of chronic obstructive pulmonary disease (COPD) is still being investigated to discover relationships with disease pathogenesis. Evidence of plasminogen activator inhibitor-1 (PAI-1) overexpression in the sputum and the blood of COPD patients is growing. We aimed to investigate the potential relation between PAI-1 promoter 4G/5G insertion/deletion polymorphism and COPD development. In a case-control study, we genotyped 117 COPD patients and 160 control subjects for PAI-1 promoter 4G/5G polymorphism by an allele-specific polymerase chain reaction analysis. All subjects were male smokers. In the co-dominant model, there was a significant difference in the distribution of 5G/5G, 4G/5G and 4G/4G genotypes between COPD patients and controls (p = 0.002). In the recessive model, carriers of 4G/4G genotype were significantly higher in COPD patients than controls (p = 0.01). Carriers of 4G/4G genotype were at higher risk to develop COPD than those carrying 5G/5G or 4G/5G genotypes (crude odds ratio (OR) = 2.10, 95% confidence interval (CI) = 1.19-3.73, adjusted OR = 2.5, 95% CI = 1.22-3.99). In conclusion, PAI-1 4G/5G genetic variations are associated with COPD development in males. |
| تدمد: | 1541-2563 1541-2555 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8220f26e7068e3081452d37c00bdce1Test https://doi.org/10.3109/15412555.2016.1168392Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c8220f26e7068e3081452d37c00bdce1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15412563 15412555 |
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