SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
| العنوان: | SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes |
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| المؤلفون: | Carmen Gomez-Guerrero, Joel Sampedro, Patricia Bogdanov, Carmen Espejo, Jesús Egido, Ignacio Prieto, Cristina Solà-Adell, Marta García-Ramírez, Cristina Hernández, Rafael Simó |
| المساهمون: | [Hernández C, Bogdanov P, Sampedro J, Solà-Adell C, García-Ramírez M, Simó R] Grup de Diabetis i Metabolisme, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Gómez-Guerrero C] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Renal, Vascular and Diabetes Research Lab, Instituto de Investigacion Sanitaria-Fundación Jimenez Diaz (IIS-FJD), Madrid, Spain. Autonoma University of Madrid (UAM), Madrid, Spain. [Espejo, C] Recerca en Neuroimmunologia clínica, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Vall d'Hebron Barcelona Hospital Campus, UAM. Departamento de Medicina |
| المصدر: | Scientia Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona International Journal of Molecular Sciences, Vol 20, Iss 15, p 3615 (2019) International Journal of Molecular Sciences Volume 20 Issue 15 Biblos-e Archivo. Repositorio Institucional de la UAM instname |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Amino Acids, Peptides, and Proteins::Amino Acids, Peptides, and Proteins::Proteins::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Suppressor of Cytokine Signaling Proteins [CHEMICALS AND DRUGS], Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy [DISEASES], aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intracelular::proteínas adaptadoras transductoras de señales::proteínas supresoras de la señalización de citocinas [COMPUESTOS QUÍMICOS Y DROGAS], medicine.medical_treatment, Pharmacology, neuroinflammation, Pathogenesis, lcsh:Chemistry, Mice, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Retina - Vasos sanguinis, lcsh:QH301-705.5, Spectroscopy, General Medicine, Diabetic retinopathy, db/db mouse, Quimiocines, Computer Science Applications, diabetic retinopathy, Cytokine, enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética [ENFERMEDADES], Medicina, Cardiovascular System::Blood-Retinal Barrier [ANATOMY], Article, Retina, Catalysis, Diabetes Mellitus, Experimental, Proinflammatory cytokine, Inorganic Chemistry, 03 medical and health sciences, Suppressor of Cytokine Signaling 1 Protein, Electroretinography, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Neuroinflammation, Inflammation, business.industry, Suppressor of cytokine signaling 1, Organic Chemistry, Retinal, suppressors of cytokine signaling, medicine.disease, sistema cardiovascular::barrera hematorretinal [ANATOMÍA], Disease Models, Animal, Db/db Mouse, 030104 developmental biology, chemistry, lcsh:Biology (General), lcsh:QD1-999, Retinopatia diabètica, 030221 ophthalmology & optometry, microvascular impairment, Ophthalmic Solutions, Peptides, business |
| الوصف: | Current treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly a ected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. Suppressors of cytokine signaling (SOCS) are cytokine-inducible proteins that function as a negative feedback loop regulating cytokine responses. On this basis, the aim of the present study was to evaluate the e ect of a SOCS1-derived peptide administered by eye drops (2 weeks) on retinal neuroinflammation and early microvascular abnormalities in a db/db mouse model. In brief, we found that SOCS1-derived peptide significantly reduced glial activation and neural apoptosis induced by diabetes, as well as retinal levels of proinflammatory cytokines. Moreover, a significant improvement of electroretinogram parameters was observed, thus revealing a clear impact of the histological findings on global retinal function. Finally, SOCS1-derived peptide prevented the disruption of the blood-retinal barrier. Overall, our results suggest that topical administration of SOCS1-derived peptide is e ective in preventing retinal neuroinflammation and early microvascular impairment. These findings could open up a new strategy for the treatment of early stages of DR This study was supported by grants from the Ministerio de Economía y Competitividad (PI16/00541, SAF2015-63696-R, PI14/00386, PI17/01495 and DTS-2017/00203) |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dd23fa2f4d9a7d58166cc4a0510858Test https://hdl.handle.net/11351/4586Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7dd23fa2f4d9a7d58166cc4a0510858 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |