Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1
| العنوان: | Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1 |
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| المؤلفون: | Justin T. Jordan, Anna R. Terry, Lee H. Schwamm, Scott R. Plotkin |
| المصدر: | Stroke. 47:60-65 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Neurofibromatosis 1, Population, 030105 genetics & heredity, Logistic regression, Odds, Young Adult, 03 medical and health sciences, 0302 clinical medicine, International Classification of Diseases, Risk Factors, medicine, Humans, Young adult, education, Stroke, Aged, Advanced and Specialized Nursing, Intracerebral hemorrhage, education.field_of_study, business.industry, Case-control study, Odds ratio, Middle Aged, medicine.disease, Hospitalization, Cerebrovascular Disorders, Case-Control Studies, Population Surveillance, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery |
| الوصف: | Background and Purpose— Although neurofibromatosis type 1 (NF1) may be associated with an incompletely understood vasculopathy, relative odds of stroke in this population is not known. Methods— Using the 1998 to 2009 US Nationwide Inpatient Sample, we performed a case–control study matching cases of NF1 to controls without such a diagnosis. We then compared the odds of stroke between the 2 groups. We used multivariable logistic regression to adjust for known or suspected confounders. Results— NF1 was associated with younger mean age at the time of stroke (41 versus 48) and a lower prevalence of stroke risk factors among adult patients. Pediatric patients with NF1, however, were more likely to have hypertension. Patients with NF1 were significantly more likely to be diagnosed with any stroke (odds ratio, 1.2; P P P P Conclusions— When compared with the general population, the odds of any type of stroke are significantly increased for patients with NF1, both adult and pediatric. This risk is most notable for hemorrhagic strokes although it is also increased for ischemic strokes in children. Physicians should be aware of the increased risk of stroke in this population, and consider stroke as a potential cause of new neurological symptoms. |
| تدمد: | 1524-4628 0039-2499 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d053b2e042f1acb51656e2f6c6dbd2Test https://doi.org/10.1161/strokeaha.115.011406Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7d053b2e042f1acb51656e2f6c6dbd2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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