Does Abnormal QT Interval Prolongation Reflect Autonomic Dysfunction in Diabetic Patients? QTc Interval Measure Versus Standardized Tests in Diabetic Autonomic Neuropathy
| العنوان: | Does Abnormal QT Interval Prolongation Reflect Autonomic Dysfunction in Diabetic Patients? QTc Interval Measure Versus Standardized Tests in Diabetic Autonomic Neuropathy |
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| المؤلفون: | M. Borra, M Veglio, P Cavallo Perin, A. Chinaglia |
| المصدر: | Diabetic Medicine. 12:302-306 |
| بيانات النشر: | Wiley, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Posture, Sensitivity and Specificity, QT interval, Cohort Studies, Diagnosis, Differential, Endocrinology, Diabetic Neuropathies, Heart Rate, Predictive Value of Tests, Diabetes mellitus, Internal medicine, Heart rate, Internal Medicine, medicine, Humans, Diabetic Autonomic Neuropathy, Analysis of Variance, medicine.diagnostic_test, business.industry, Respiration, Middle Aged, medicine.disease, Long QT Syndrome, Diabetes Mellitus, Type 1, Blood pressure, Cough, Diabetes Mellitus, Type 2, Predictive value of tests, Cardiology, Regression Analysis, Female, Analysis of variance, business, Electrocardiography |
| الوصف: | The question as to whether the QTc interval correlates with five cardiovascular tests (deep breathing test, 30/15 ratio test, lying to standing test, cough test, and postural blood pressure test) for the diagnosis of diabetic autonomic neuropathy (DAN) was investigated in 168 (38 Type 1, 130 Type 2) consecutive outpatients (mean age 54.9 +/- 11.2 years). QT interval was measured on an ECG recorded at rest and QTc calculated according to Bazett's formula. The percentage of patients with a QTc greater than 0.440 s was: absent DAN = 11% (n = 7), probable DAN = 7% (n = 4), definite DAN = 23% (n = 12) (p < 0.05), and the mean (+/- SD) QTc values were 0.403 +/- 0.028 s, 0.405 +/- 0.023 s, and 0.421 +/- 0.026 s, respectively. A significant correlation between QTc duration and DAN score of autonomic cardiovascular test results (r = 0.34, p < 0.0001) was observed. The calculated specificity, sensitivity, positive and negative predictive values were 89%, 15%, 70% and 37%, respectively. In conclusion, QTc can be considered as an additional specific test in the assessment of diabetic autonomic neuropathy, but cannot replace the standard battery of cardiovascular tests. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c780f8191fe9d1e5596614dd13ef3e43Test https://doi.org/10.1111/j.1464-5491.1995.tb00481.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c780f8191fe9d1e5596614dd13ef3e43 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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