Clinical management and disease-modifying treatment for amyotrophic lateral sclerosis in African hospital centers: the TROPALS study
| العنوان: | Clinical management and disease-modifying treatment for amyotrophic lateral sclerosis in African hospital centers: the TROPALS study |
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| المؤلفون: | Lamia Ali Pacha, Anna Modji Basse, Noudy Sengxeu, Jaime Luna, Dieudonné Gnonlonfoun, Philippe Couratier, Meriem Tazir, Leila Ait Aissa, Jeremy Jost, M Belo, Riadh Gouider, Franclo Henning, Dismand Houinato, Ousmane Cisse, Mendinatou Agbétou, Aa Koffi Balogou, Damelan Kombate, Mouhamadou Diagana, Pierre-Marie Preux, Marin Benoit, Thierry Agba, Athanase Millogo, Bello Hamidou, Imen Kacem |
| المساهمون: | Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacie Centrale [CHU Limoges], CHU Limoges, Service de Neurologie, C.H.U Mustapha Bacha, Place du 1er Mai, 16000 Alger, Algeria, Hopital de Razi - Razi Hospital [Tunis], Stellenbosch University, CHNU Fann Dakar, Service de Neurologie, CHU Campus Université de Lomé, Service de Neurologie, CHU Campus Université de Lomé-Service de Neurologie, CHU Campus Université de Lomé, Centre National Hospitalier Universitaire Hubert K. Maga de Cotonou (CNHU-HKM), Laboratory of Chronic and Neurological Diseases Epidemiology (LEMACEN), University of Abomey Calavi (UAC), Université Joseph Ki-Zerbo [Ouagadougou] (UJZK), Université de Lomé [Togo], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de Neurologie [CHU Limoges] |
| المصدر: | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis, 2021, pp.1-5. ⟨10.1080/21678421.2021.1961806⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, availability, Disease, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary approach, Health care, medicine, Humans, Amyotrophic lateral sclerosis, 030304 developmental biology, 0303 health sciences, affordability, business.industry, medicine.disease, riluzole, Hospitals, 3. Good health, Riluzole, Neurology, Who guidelines, Family medicine, Africa, Observational study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), business, 030217 neurology & neurosurgery, management, medicine.drug |
| الوصف: | International audience; Objective: To assess the availability of health workers and medications for clinical management of amyotrophic lateral sclerosis (ALS) in African hospital centers. Availability and affordability analyses of disease-modifying treatments were performed. Methods: A multicenter observational study involving African hospitals was conducted. A standard questionnaire was developed based on the European Federation of the Neurological Societies (EFNS) guidelines. We collected data on multidisciplinary care and availability of medicines. The availability and affordability were evaluated according to the WHO guidelines. Results: Nine hospital centers from eight African countries participated. We observed a low degree of implementation of multidisciplinary care in ALS management. Riluzole was only available in centers from South Africa, Senegal, Tunisia, and Togo. This treatment was unaffordable and the adjusted price was highly variable among countries. The cost of riluzole was partly or fully covered by patients, which implies a substantial economic burden. Conclusion: Our findings strengthen the need to promote multidisciplinary care in the clinical management of ALS in Africa. Disease-modifying medication should be both available and affordable. Local and international collaboration is needed to improve ALS health care access in Africa. |
| اللغة: | English |
| تدمد: | 2167-8421 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75c932c14328fd386c59aa86fc735c8Test https://hal-unilim.archives-ouvertes.fr/hal-03339802Test |
| رقم الانضمام: | edsair.doi.dedup.....c75c932c14328fd386c59aa86fc735c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21678421 |
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