The composition of polypharmacy: A register-based study of Swedes aged 75 years and older
| العنوان: | The composition of polypharmacy: A register-based study of Swedes aged 75 years and older |
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| المؤلفون: | Angel Cedazo Minguez, Jonas W. Wastesson, Silvia Maioli, Kristina Johnell, Johan Fastbom |
| المصدر: | PLoS ONE, Vol 13, Iss 3, p e0194892 (2018) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Register based, Male, European People, Social Sciences, lcsh:Medicine, Swedish People, Total population, 030204 cardiovascular system & hematology, Geographical locations, Drug Users, 0302 clinical medicine, Elderly, Medicine and Health Sciences, Psychology, Ethnicities, Drug Interactions, 030212 general & internal medicine, Registries, lcsh:Science, media_common, Geriatrics, Aged, 80 and over, Analgesics, Multidisciplinary, Drug Information, Drugs, Addicts, Europe, Female, Research Article, Drug, medicine.medical_specialty, media_common.quotation_subject, MEDLINE, Addiction, Drug-Drug Interactions, Drug Prescriptions, Drug register, 03 medical and health sciences, medicine, Humans, Pain Management, European Union, Aged, Polypharmacy, Sweden, Pharmacology, Entire population, business.industry, lcsh:R, Biology and Life Sciences, Age Groups, People and Places, Population Groupings, lcsh:Q, business, Anxiolytics, Demography |
| الوصف: | Background Polypharmacy is common among older adults. However, little is known about the composition of polypharmacy: which are the most frequently used drugs, and how much do these drugs contribute to the overall prevalence of polypharmacy. Methods A total of 822,619 Swedes aged ≥75 years was identified from the Total Population Register. Through record-linkage with the Swedish Prescribed Drug Register and the Social Services Register we could analyze concurrent drug use in the entire population (both individuals living in the community and institution) on the 31 December 2013. Results The prevalence of polypharmacy (≥5 drugs) was 45%. The most frequently used drugs were cardiovascular drugs, analgesics, and psychotropics. By excluding the ten most frequently used drug classes or compounds, the prevalence of polypharmacy was reduced by 69% and 51% respectively. The majority of the users of either one of the 10 most frequently used drugs concurrently used at least 4 other drug classes (66%-85%). Conclusion Almost half of the individuals aged ≥75 years are exposed to polypharmacy in Sweden. A handful of drugs make a large contribution to the overall prevalence of polypharmacy and the majority of drugs prescribed to persons aged ≥75 years are used in combination with other drugs. This highlights the high use of drugs, and the need to consider other concurrent drug treatments when prescribing for older adults. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c646e62a8109f002eff10a16faf16649Test http://europepmc.org/articles/PMC5875802?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c646e62a8109f002eff10a16faf16649 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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