WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2
| العنوان: | WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2 |
|---|---|
| المؤلفون: | Livia Goto-Silva, Carolina Q. Sacramento, Marília Zaluar P. Guimarães, Rafael Dariolli, Isis M. Ornelas, Thiago Moreno L. Souza, Estela Cruvinel, Luiz Guilherme H. S. Aragão, Jairo R. Temerozo, Helena L. Borges, Teresa Puig-Pijuan, Júlia T. Oliveira, Diogo Biagi, José Alexandre Salerno, Daniel Rodrigues Furtado, Thayana Torquato, Stevens K. Rehen, Karina Karmirian, Natalia Fintelman-Rodrigues, Patrícia T. Bozza, Mayara Abud Mendes, Vinicius Cardoso Soares, Leticia R. Q. Souza, Carolina da S. G. Pedrosa, Carla Veríssimo, Gabriela Vitória, Suelen da Silva Gomes Dias |
| المصدر: | PeerJ PeerJ, Vol 9, p e12262 (2021) |
| بيانات النشر: | PeerJ Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Agonist, Cannabinoid receptor, medicine.drug_class, medicine.medical_treatment, SARS-Cov-2, Cardiology, Inflammation, Pharmacology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Immune system, Lactate dehydrogenase, Virology, WIN 55,212-2, Medicine, Cytotoxic T cell, Molecular Biology, health care economics and organizations, Coronavirus, Human iPSC-derived cardiomyocytes, business.industry, Cannabinoids, General Neuroscience, Interleukin, COVID-19, General Medicine, Cell Biology, medicine.disease, chemistry, Immunology, Tumor necrosis factor alpha, Cannabinoid, medicine.symptom, General Agricultural and Biological Sciences, business, Cytokine storm, medicine.drug |
| الوصف: | Coronavirus disease 2019 (COVID-19) is caused by acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can infect several organs and lead to loss of vital organ function, especially impacting respiratory capacity. Among the extrapulmonary manifestations of COVID-19 is myocardial injury, caused both directly and indirectly by SARS-CoV-2, and which is associated with a high risk of mortality. One of the hallmarks of severe COVID-19 is the "cytokine storm", at which point the immune system malfunctions, leading to possible organ failure and death. Cannabinoids are known to have anti-inflammatory properties by negatively modulating the release of pro-inflammatory cytokines. Herein, we investigated the effects of the cannabinoid agonist WIN 55,212-2 (WIN) on SARS-CoV-2-infected human iPSC-derived cardiomyocytes (hiPSC-CMs). Although WIN did not modulate angiotensin-converting enzyme II, nor reduced SARS-CoV-2 infection and replication in hiPSC-CMs at the conditions tested, it had anti-inflammatory and protective effects by reducing the levels of interleukins 6, 8,18 and tumor necrosis factor-alpha (TNF-) and lactate dehydrogenase (LDH) activity in these cells without causing hypertrophic cardiac damage. These findings suggest that cannabinoids should be further investigated as an alternative therapeutic tool for the treatment of COVID-19. HighlightsO_LIHuman iPSC-derived cardiomyocytes (hiPSC-CMs) express CB1 receptor. C_LIO_LIThe cannabinoid receptor agonist, WIN 55,212-2 (WIN), does not influence SARS-CoV-2 infection in hiPSC-CMs. C_LIO_LIWIN reduces inflammation and death in SARS-CoV-2-infected hiPSC-CMs. C_LI |
| اللغة: | English |
| تدمد: | 2167-8359 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60f15579adba1dddbc2a6c4574dab9dTest http://europepmc.org/articles/PMC8504461Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c60f15579adba1dddbc2a6c4574dab9d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21678359 |
|---|