Low skeletal muscle mass is associated with more severe histological features of non-alcoholic fatty liver disease in male
| العنوان: | Low skeletal muscle mass is associated with more severe histological features of non-alcoholic fatty liver disease in male |
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| المؤلفون: | Xiao-Yan Pan, Wen-Yue Liu, Pei-Wu Zhu, Gang Li, Liang-Jie Tang, Feng Gao, Ou-Yang Huang, Hai-Yang Yuan, Giovanni Targher, Christopher D. Byrne, Xiao-Dong Wang, Ming-Hua Zheng |
| المصدر: | Hepatology International. 16:1085-1093 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Sarcopenia, Hepatology, Patatin-like phospholipase domain-containing 3, Membrane Proteins, Skeletal, Single Nucleotide, Lipase, Polymorphism, Single Nucleotide, Skeletal muscle mass, Liver, Non-alcoholic Fatty Liver Disease, Phospholipases, Creatinine, Muscle, Humans, Genetic Predisposition to Disease, Polymorphism, Muscle, Skeletal |
| الوصف: | Although low skeletal muscle mass is associated with non-alcoholic fatty liver disease (NAFLD), it is currently uncertain whether there are associations between weight-adjusted appendicular skeletal muscle (ASM%), severity of histological features of NAFLD, and the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism. Our aim was to test for a possible influence of the PNPLA3 rs738409 variant on the association between ASM% and severity of NAFLD histological features.We enrolled 401 Chinese male with biopsy-proven NAFLD. Using a bioelectrical-impedance body composition analyzer (BIA, Inbody 720, Japan Inc., Tokyo), we calculated the ASM% as the percentage of total appendicular skeletal muscle mass (ASM, kg)/total body mass (kg) × 100.Compared to those with high ASM%, patients with low ASM% (≤ 30.6, i.e., the median value of distribution of the whole sample) had a greater severity of individual histological features of NAFLD. These patients also had a higher risk of severe steatosis and non-alcoholic steatohepatitis (NASH) (adjusted-odds ratio [OR] 2.34, 95% CI 1.39-3.93, and adjusted-OR 2.22, 95% CI 1.30-3.77) even after adjusting for age, body mass index, diabetes, and serum creatinine levels. Carriage of the G allele of PNPLA3 rs738409 plus low ASM% was associated with a higher risk of severe steatosis and presence of liver fibrosis (OR 3.02, 95% CI 1.46-6.26, p = 0.003 and OR 2.18, 95% CI 1.03-4.60, p = 0.041 respectively), and there was a non-significant but borderline increased risk of NASH (OR 2.00, 95% CI 0.98-4.06, p = 0.056).Low ASM% and the presence of a G allele within PNPLA3 rs738409 is associated with more severe histological features of NAFLD. |
| وصف الملف: | text; image |
| تدمد: | 1936-0541 1936-0533 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d17107bc34dc219e4b9f0eac8b44b2Test https://doi.org/10.1007/s12072-022-10384-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c5d17107bc34dc219e4b9f0eac8b44b2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19360541 19360533 |
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