Sinonasal Paraganglioma With Long-Delayed Recurrence and Metastases: Genetic and Imaging Findings
| العنوان: | Sinonasal Paraganglioma With Long-Delayed Recurrence and Metastases: Genetic and Imaging Findings |
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| المؤلفون: | Michel Wassef, Marianne Jolibert, Nicolas Fakhry, Julia Torrents, Justin Michel, Anne Barlier, Wassim Essamet, Patrick Dessi, David Taïeb, Isabelle Morange |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 98:4262-4266 |
| بيانات النشر: | The Endocrine Society, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, SDHB, Endocrinology, Diabetes and Metabolism, Nose Neoplasms, Clinical Biochemistry, Context (language use), Malignancy, Multimodal Imaging, Biochemistry, Paraganglioma, Endocrinology, Paranasal Sinuses, medicine, Medical imaging, Humans, medicine.diagnostic_test, business.industry, Biochemistry (medical), Endoscopy, Middle Aged, medicine.disease, Primary tumor, Positron emission tomography, Positron-Emission Tomography, SDHD, Radiology, Neoplasm Recurrence, Local, Tomography, X-Ray Computed, business |
| الوصف: | Context: Sinonasal paragangliomas have rarely been reported in the literature. They are often aggressive. Patient: We report an original case of sinonasal paragangliomas with a tumor recurrence diagnosed 13 years after resection of the primary tumor. Somatostatin receptor scintigraphy and [18F]-fluorodeoxyglucose positron emission tomography/computed tomography were the most sensitive functional imaging techniques, and they ruled out distant metastases. Interestingly, [18F]-fluorodihydroxyphenylalanine positron emission tomography/computed tomography was negative, a feature that may be considered a sign of functional dedifferentiation. Screening for germline mutations of the SDHB, SDHC, SDHD, SDHAF2, VHL, MAX, and TMEM127 was negative. Conclusion: The diagnosis of malignancy remains challenging at initial diagnosis, and patients should be followed during their entire lifetime. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d02acc92089935bbbc3610961151c8Test https://doi.org/10.1210/jc.2013-2320Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c5d02acc92089935bbbc3610961151c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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