Respiratory syncytial virus among children hospitalized with severe acute respiratory infection in Kashmir, a temperate region in northern India
| العنوان: | Respiratory syncytial virus among children hospitalized with severe acute respiratory infection in Kashmir, a temperate region in northern India |
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| المؤلفون: | Parvaiz A Koul, Siddhartha Saha, Kaisar A Kaul, Hyder Mir, Varsha Potdar, Mandeep Chadha, Danielle Iuliano, Kathryn E Lafond, Renu B Lal, Anand Krishnan |
| المصدر: | Journal of Global Health. 12 |
| بيانات النشر: | International Global Health Society, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Hospitalization, Respiratory Syncytial Virus, Human, Health Policy, Influenza, Human, Public Health, Environmental and Occupational Health, Humans, Infant, Pneumonia, Respiratory Syncytial Virus Infections, Child, Respiratory Tract Infections, Phylogeny |
| الوصف: | Severe acute respiratory infections (SARI) are a leading cause of hospitalizations in children, especially due to viral pathogens. We studied the prevalence of respiratory viruses among children aged5 years hospitalized with severe acute respiratory infections (SARI) in Kashmir, India.We conducted a prospective observational study in two tertiary care hospitals from October 2013 to September 2014, systematically enrolling two children aged5 years with SARI per day. We defined SARI as history of fever or measured fever (≥38°C) and cough with onset in the last 7 days requiring hospitalization for children aged 3-59 months and as physician-diagnosed acute lower respiratory infection for children aged3 months. Trained study staff screened children within 24 hours of hospitalization for SARI and collected clinical data and nasopharyngeal swabs from enrolled participants. We tested for respiratory syncytial virus (RSV) A and B, influenza viruses, rhinoviruses (HRV)/enteroviruses, adenovirus (AdV), bocavirus (BoV), human metapneumovirus (hMPV) A and B, coronaviruses (OC43, NL65, C229E), and parainfluenza viruses (PIV) 1, 2, 3 and 4 using standardized duplex real-time polymerase chain reaction.Among 4548 respiratory illness admissions screened from October 2013 to September 2014, 1026 met the SARI case definition, and 412 were enrolled (ages = 5 days to 58 months; median = 12 months). Among enrolees, 256 (62%) were positive for any virus; RSV was the most commonly detected (n = 118, 29%) followed by HRV/enteroviruses (n = 88, 21%), PIVs (n = 31, 8%), influenza viruses (n = 18, 4%), BoV (n = 15, 4%), coronaviruses (n = 16, 4%), AdV (n = 14, 3%), and hMPV (n = 9, 2%). Fifty-four children had evidence of virus co-detection. Influenza-associated SARI was more common among children aged 1-5 years (14/18, 78%) while most RSV detections occurred in children12 months (83/118, 70%). Of the RSV viruses typed (n = 116), the majority were type B (94, 80%). Phylogenetic analysis of G gene of RSV showed circulation of the BA9 genotype with 60bp nucleotide duplication.Respiratory viruses, especially RSV, contributed to a substantial proportion of SARI hospitalizations among children5 years in north India. These data can help guide clinicians on appropriate treatment and prevention strategies. |
| تدمد: | 2047-2986 2047-2978 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fa59ce9bd186f422773346d05e8bc6Test https://doi.org/10.7189/jogh.12.04050Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4fa59ce9bd186f422773346d05e8bc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20472986 20472978 |
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