Prognostic value of FGFR1 expression and amplification in patients with HNSCC: A systematic review and meta-analysis
| العنوان: | Prognostic value of FGFR1 expression and amplification in patients with HNSCC: A systematic review and meta-analysis |
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| المؤلفون: | Liu-Qing Zhou, Lisha Ai, Yao Hu |
| المصدر: | PLoS ONE PLoS ONE, Vol 16, Iss 5, p e0251202 (2021) |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Fibroblast Growth Factor, Physiology, Lung and Intrathoracic Tumors, Database and Informatics Methods, Endocrinology, Mathematical and Statistical Techniques, 0302 clinical medicine, Breast Tumors, Medicine and Health Sciences, Database Searching, Aged, 80 and over, Multidisciplinary, Statistics, Metaanalysis, Middle Aged, Prognosis, Head and Neck Tumors, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Meta-analysis, Physical Sciences, Medicine, Research Article, Adult, medicine.medical_specialty, Science, Subgroup analysis, Research and Analysis Methods, Young Adult, 03 medical and health sciences, Head and Neck Squamous Cell Carcinoma, stomatognathic system, Growth Factors, Internal medicine, Breast Cancer, Biomarkers, Tumor, medicine, Humans, In patient, Squamous Cell Carcinoma, Receptor, Fibroblast Growth Factor, Type 1, Statistical Methods, Aged, Endocrine Physiology, Squamous Cell Carcinoma of Head and Neck, business.industry, HPV Positive, Fibroblast growth factor receptor 1, Carcinoma, Gene Amplification, Cancers and Neoplasms, Biology and Life Sciences, Cancer, medicine.disease, Head and neck squamous-cell carcinoma, Confidence interval, stomatognathic diseases, 030104 developmental biology, Head and Neck Cancers, business, Mathematics |
| الوصف: | Fibroblast growth factor receptor 1 (FGFR1) has recently been identified as a promising novel therapeutic target and prognostic marker in different types of cancer. In the present study, a meta-analysis was performed to clarify the correlation between FGFR1 and the survival outcomes of head and neck squamous cell carcinoma (HNSCC) patients. PubMed, Embase, and Web of Science were systematically searched for relevant studies in order to explore the prognostic significance of FGFR1 in HNSCC. Hazards ratios (HR) and 95% confidence intervals (CI) were collected to estimate the correlation between overexpression and amplification of FGFR1 and survival outcomes of HNSCC patients. Nine studies including 2708 patients with HNSCC were finally selected for the meta-analysis. The results indicated that FGFR1 predicted poor overall survival (OS) (HR, 1.97; 95% CI, 1.49–2.61, P |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bf7ebde21a618e0a4fcc37c6e586cfTest https://doi.org/10.1371/journal.pone.0251202Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4bf7ebde21a618e0a4fcc37c6e586cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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