Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning
| العنوان: | Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning |
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| المؤلفون: | Ruta Brazauskas, Gérard Socié, Brian J. Bolwell, Zhiwei Wang, Mary M. Horowitz, Ronald Sobecks, John R. Wingard, Navneet S. Majhail, J. Douglas Rizzo |
| المصدر: | Blood. 117:316-322 |
| بيانات النشر: | American Society of Hematology, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Transplantation Conditioning, Adolescent, Cyclophosphamide, medicine.medical_treatment, Immunology, Population, Hematopoietic stem cell transplantation, Biochemistry, Cohort Studies, Young Adult, Risk Factors, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Transplantation, Homologous, Child, education, Busulfan, Retrospective Studies, Transplantation, education.field_of_study, business.industry, Remission Induction, Hematopoietic Stem Cell Transplantation, Myeloid leukemia, Cancer, Neoplasms, Second Primary, Cell Biology, Hematology, Middle Aged, medicine.disease, Survival Rate, Leukemia, Myeloid, Acute, Leukemia, Treatment Outcome, Female, business, medicine.drug |
| الوصف: | Risks of secondary solid cancers among allogeneic hematopoietic cell transplant (HCT) recipients who receive conditioning without total body irradiation are not well known. We evaluated the incidence and risk factors for solid cancers after HCT using high-dose busulfan-cyclophosphamide conditioning in 4318 recipients of first allogeneic HCT for acute myeloid leukemia in first complete remission (N = 1742) and chronic myeloid leukemia in first chronic phase (N = 2576). Our cohort represented 22 041 person-years at risk. Sixty-six solid cancers were reported at a median of 6 years after HCT. The cumulative-incidence of solid cancers at 5 and 10 years after HCT was 0.6% and 1.2% among acute myeloid leukemia and 0.9% and 2.4% among chronic myeloid leukemia patients. In comparison to general population incidence rates, HCT recipients had 1.4× higher than expected rate of invasive solid cancers (95% confidence interval, 1.08-1.79, P = .01). Significantly elevated risks were observed for tumors of the oral cavity, esophagus, lung, soft tissue, and brain. Chronic graft-versus-host disease was an independent risk factor for all solid cancers, and especially cancers of the oral cavity. Recipients of allogeneic HCT using busulfan-cyclophosphamide conditioning are at risk for developing solid cancers. Their incidence continues to increase with time, and lifelong cancer surveillance is warranted in this population. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b862f64ad7cd4ba1d7254ea6607cf5Test https://doi.org/10.1182/blood-2010-07-294629Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4b862f64ad7cd4ba1d7254ea6607cf5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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