Improved Progression Prediction in Barrett's Esophagus With Low-grade Dysplasia Using Specific Histologic Criteria
| العنوان: | Improved Progression Prediction in Barrett's Esophagus With Low-grade Dysplasia Using Specific Histologic Criteria |
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| المؤلفون: | Leendert H. J. Looijenga, Daan Nieboer, Fiebo J C Ten Kate, Fiebo J.W. ten Kate, Michail Doukas, Manon C.W. Spaander, Marco J. Bruno, Katharina Biermann |
| المساهمون: | Pathology, Public Health, Gastroenterology & Hepatology |
| المصدر: | American Journal of Surgical Pathology, 42(7), 918-926. Lippincott Williams & Wilkins |
| بيانات النشر: | Lippincott Williams & Wilkins, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Esophageal Neoplasms, Biopsy, education, Mitosis, Adenocarcinoma, Risk Assessment, Gastroenterology, Pathology and Forensic Medicine, Barrett Esophagus, 03 medical and health sciences, Esophagus, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Aged, Observer Variation, medicine.diagnostic_test, business.industry, Hazard ratio, Mucins, Reproducibility of Results, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, Confidence interval, medicine.anatomical_structure, Dysplasia, Cell Nucleus Size, 030220 oncology & carcinogenesis, Predictive value of tests, Barrett's esophagus, Disease Progression, Female, 030211 gastroenterology & hepatology, Surgery, Esophagoscopy, Tumor Suppressor Protein p53, Anatomy, business, Kappa |
| الوصف: | Risk stratification of patients with Barrett's esophagus (BE) is based on diagnosis of low-grade dysplasia (LGD). LGD has a poor interobserver agreement and a limited value for prediction of progression to high-grade dysplasia or esophageal adenocarcinoma. Specific reproducible histologic criteria may improve the predictive value of LGD. Four gastrointestinal pathologists examined 12 histologic criteria associated with LGD in 84 BE patients with LGD (15 progressors and 69 nonprogressors). The criteria with at least a moderate (kappa, 0.4 to 0.6) interobserver agreement were validated in an independent cohort of 98 BE patients with LGD (30 progressors and 68 nonprogressors). Hazard ratios (HR) were calculated by Cox proportional hazard regression analysis using time-dependent covariates correcting for multiple endoscopies during follow-up. Agreement was moderate or good for 4 criteria, that is, loss of maturation, mucin depletion, nuclear enlargement, and increase of mitosis. Combination of the criteria differentiated high-risk and low-risk group amongst patients with LGD diagnosis (P |
| تدمد: | 1532-0979 0147-5185 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b41575eb1322c09528c39112fec6ceTest https://doi.org/10.1097/pas.0000000000001066Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c4b41575eb1322c09528c39112fec6ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15320979 01475185 |
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