ENDOCRINOLOGY OF PREGNANCY: Gestational diabetes mellitus: definition, aetiological and clinical aspects
| العنوان: | ENDOCRINOLOGY OF PREGNANCY: Gestational diabetes mellitus: definition, aetiological and clinical aspects |
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| المؤلفون: | Baz Baz, Jean-François Gautier, Jean-Pierre Riveline |
| المصدر: | European Journal of Endocrinology. 174:R43-R51 |
| بيانات النشر: | Oxford University Press (OUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Type 2 diabetes, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Pregnancy, Diabetes mellitus, Internal medicine, medicine, Humans, Glucose homeostasis, 030212 general & internal medicine, Obstetrics, business.industry, Insulin, nutritional and metabolic diseases, General Medicine, medicine.disease, female genital diseases and pregnancy complications, Gestational diabetes, Diabetes, Gestational, Female, business, Hyperinsulinism |
| الوصف: | Gestational diabetes (GDM) is defined as a glucose intolerance resulting in hyperglycaemia of variable severity with onset during pregnancy. This review aims to revisit the pathogenesis and aetiology of GDM in order to better understand its clinical presentation and outcomes. During normal pregnancy, insulin sensitivity declines with advancing gestation. These modifications are due to placental factors, progesterone and estrogen. In a physiological situation, a compensatory increase in insulin secretion maintains a normal glucose homeostasis. GDM occurs if pancreatic β-cells are unable to face the increased insulin demand during pregnancy. GDM is most commonly a forerunner of type 2 diabetes (T2D) – the most prevalent form of diabetes. These women share similar characteristics with predisposed subjects to T2D: insulin resistance before and after pregnancy, and carry more T2D risk alleles. Auto-immune and monogenic diabetes are more rare aetiologies of GDM. Adverse pregnancy outcomes of GDM are mainly related to macrosomia caused by fetal hyperinsulinism in response to high glucose levels coming from maternal hyperglycaemia. Screening recommendations and diagnosis criteria of GDM have been recently updated. High risk patients should be screened as early as possible using fasting plasma glucose, and if normal, at 24–28 weeks of gestation using 75 g oral glucose tolerance test. The treatment of GDM is based on education with trained nurses and dieticians, and if necessary insulin therapy. |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3afa722b30bacfa46034abad1d1ce74Test https://doi.org/10.1530/eje-15-0378Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c3afa722b30bacfa46034abad1d1ce74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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