Clinical Significance of Screening Electrocardiograms for the Administration of Propranolol for Problematic Infantile Hemangiomas
| العنوان: | Clinical Significance of Screening Electrocardiograms for the Administration of Propranolol for Problematic Infantile Hemangiomas |
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| المؤلفون: | Jenika Sanchez, R. Thomas Collins, Larry D. Hartzell, Gresham T. Richter, J. Reed Gardner, Tyler Merrill, James D. Phillips, Jay M. Kincannon, Adam B. Johnson, Brian K. Eble |
| المصدر: | International Journal of Pediatrics, Vol 2021 (2021) International Journal of Pediatrics |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Article Subject, Premature atrial contraction, Heart block, Propranolol, Pediatrics, RJ1-570, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Ventricular hypertrophy, 030225 pediatrics, Internal medicine, Medicine, Effective treatment, Clinical significance, Abnormal Finding, cardiovascular diseases, business.industry, medicine.disease, Pediatrics, Perinatology and Child Health, Cohort, Cardiology, business, Research Article, medicine.drug |
| الوصف: | Objective. Low-dose nonselective β blockade is an effective treatment for problematic infantile hemangioma (PIH). Screening electrocardiograms (ECG) are performed prior to the initiation of propranolol to minimize the risk of exacerbating undiagnosed heart block. How ECG results affect subsequent propranolol usage and patient management remains unclear. We examined the value of ECG prior to propranolol therapy in a quaternary pediatric hospital. Methods. A retrospective chart review was performed on all infants who received propranolol (2 mg/kg/day divided three times daily) to treat PIH at Arkansas Children’s Hospital from Sept. 2008 to Sept. 2015. All available demographic, historical, and clinical data were obtained. ECGs and echocardiographic data were reviewed and summarized. A pediatric cardiologist read all ECGs. Results. A total of 333 patients (75% female) received propranolol therapy. ECG information was available for 317 (95%). Abnormal findings were present on 44/317 (13.9%) of study ECGs. The most common abnormal finding was “voltage criteria for ventricular hypertrophy” ( n = 35 , 76.1%). Two patients had abnormal rhythms; one had first-degree atrioventricular (AV) block, and one had occasional premature atrial contractions. Of the 31 patients who underwent echocardiograms, 20 (35%) were abnormal. 2.9% of infants with PIH treated with propranolol required a follow-up with a cardiologist. No patient was precluded from taking propranolol due to the findings on screening ECG. Conclusions. Screening ECGs prior to propranolol therapy are abnormal in nearly 14% of patients with PIH but are unlikely to preclude therapy. In the absence of prior cardiac history, this cohort offers further evidence suggesting that screening ECGs may be of limited value in determining the safety of propranolol in otherwise healthy infants with PIH. |
| وصف الملف: | text/xhtml |
| تدمد: | 1687-9759 1687-9740 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39eb39e5d1f420cbe6dce41676ca0b5Test https://doi.org/10.1155/2021/6657796Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c39eb39e5d1f420cbe6dce41676ca0b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16879759 16879740 |
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