Type 1 Diabetes and Non-Alcoholic Fatty Liver Disease: When Should We Be Concerned? A Nationwide Study in Brazil
| العنوان: | Type 1 Diabetes and Non-Alcoholic Fatty Liver Disease: When Should We Be Concerned? A Nationwide Study in Brazil |
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| المؤلفون: | Deborah Conte Santos, Marcela Haas Pizarro, Marília B. Gomes, Laura Gomes Nunes del Melo, Bianca Senger Vasconcelos Barros |
| المصدر: | Nutrients, Vol 9, Iss 8, p 878 (2017) Nutrients; Volume 9; Issue 8; Pages: 878 Nutrients |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, obesity, Adolescent, type 1 diabetes, Population, 030209 endocrinology & metabolism, lcsh:TX341-641, Disease, liver, Gastroenterology, Article, metabolic syndrome, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Risk Factors, Internal medicine, NAFLD, medicine, Humans, 030212 general & internal medicine, Risk factor, education, Acanthosis nigricans, Type 1 diabetes, education.field_of_study, Nutrition and Dietetics, business.industry, Data Collection, aminotransferase, Fatty liver, nutritional and metabolic diseases, Alanine Transaminase, medicine.disease, Obesity, digestive system diseases, Endocrinology, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, Metabolic syndrome, business, lcsh:Nutrition. Foods and food supply, Brazil, Food Science |
| الوصف: | Obesity is increasing worldwide, affecting even patients with type 1 diabetes (T1D). A higher prevalence of associated comorbidities is expected, such as non-alcoholic fatty liver disease (NAFLD). This paper reports a cross-sectional multicenter study on a population with T1D (n = 1662), which aimed to evaluate the prevalence of metabolic syndrome (MS), a known risk factor for NAFLD, and to investigate predisposing factors associated with MS, as well as factors associated with elevated alanine aminotransferase (ALT), as it correlates to liver fat content. Patients were from 14 public clinics of 10 cities from all geographical regions of Brazil. A high prevalence of MS was found, especially among adults (32.3%), and this was related to age, female gender, acid uric levels, and the presence of acanthosis nigricans. ALT above the normal range was associated with triglyceride levels (especially above 129.5 mg/dL), serum uric acid, age, male gender, HbA1c, and non-Caucasian ethnicity. Patients with T1D, metabolic syndrome, and the aforementioned factors may be at a higher risk of NAFLD and should be referred to ultrasound for NAFLD evaluation. Further studies are necessary to establish the prevalence of NAFLD in individuals with T1D and to determine the disease’s progression in these patients. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d3413f3846aeed8fb6abb1d32248deTest https://www.mdpi.com/2072-6643/9/8/878Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c2d3413f3846aeed8fb6abb1d32248de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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