Safety profile of low‐titer group O whole blood in pediatric patients with massive hemorrhage
| العنوان: | Safety profile of low‐titer group O whole blood in pediatric patients with massive hemorrhage |
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| المؤلفون: | Christine M. Leeper, Mark H. Yazer, Barbara A. Gaines, Katrina M Morgan, Stephen Strotmeyer, Darrell J. Triulzi |
| المصدر: | Transfusion. 61 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Bilirubin, Immunology, Hemolysis, ABO Blood-Group System, chemistry.chemical_compound, Lactate dehydrogenase, Internal medicine, Humans, Immunology and Allergy, Medicine, Blood Transfusion, Child, Adverse effect, Whole blood, Creatinine, biology, business.industry, Haptoglobin, Transfusion Reaction, Hematology, medicine.disease, chemistry, Child, Preschool, biology.protein, Female, business, Pediatric trauma |
| الوصف: | BACKGROUND: Low-titer Group O Whole Blood (LTOWB) is used with increasing frequency in adult and pediatric trauma and massive bleeding transfusion protocols. There is a risk of acute hemolytic reactions in non-group O recipients due to the passive transfusion of anti-A and anti-B in the LTOWB. This study investigated the hemolysis risk among pediatric recipients of LTOWB. STUDY DESIGN AND METHODS: Blood bank records were queried for pediatric recipients of LTOWB between June 2016 and August 2020 and merged with clinical data. The primary outcome was laboratory evidence of hemolysis as manifested by changes in lactate dehydrogenase (LDH), haptoglobin, total bilirubin, reticulocyte count, potassium, and creatinine. Per protocol, these values were collected on hospital days 0-2 for recipients of LTOWB. Transfusion reactions were reported to the hospital's blood bank. RESULTS: Forty-seven children received LTOWB transfusion between 2016 and 2020; 21 were group O and 26 were non-group O. The groups were comparable in terms of the total volume of transfused blood products, demographics, and clinical outcomes. The most common indication for LTOWB transfusion was hemorrhagic shock due to trauma. There were no clinically or statistically significant differences in baseline, post-transfusion day 1, or post-transfusion day 2 hemolysis markers between the group O and non-group O LTOWB recipients. There were no adverse events or transfusion reactions reported. DISCUSSION: Use of up to 40 ml/kg of LTOWB appears to be serologically safe for children in hemorrhagic shock. |
| تدمد: | 1537-2995 0041-1132 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aca65b83e2bd282c62f57ac721f90bTest https://doi.org/10.1111/trf.16456Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c2aca65b83e2bd282c62f57ac721f90b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15372995 00411132 |
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