Motor cortical excitability and plasticity in patients with neurofibromatosis type 1
| العنوان: | Motor cortical excitability and plasticity in patients with neurofibromatosis type 1 |
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| المؤلفون: | Steven A. Kushner, Myrthe J. Ottenhoff, Ype Elgersma, Jesminne Castricum, Walter Taal, Joke H.M. Tulen |
| المساهمون: | Neurosciences, Psychiatry, Neurology |
| المصدر: | Clinical Neurophysiology, 131(11), 2673-2681. Elsevier Ireland Ltd |
| بيانات النشر: | Elsevier Ireland Ltd, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, Neurofibromatosis 1, Adolescent, medicine.medical_treatment, Stimulation, 050105 experimental psychology, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Physiology (medical), Neuroplasticity, Medicine, Humans, 0501 psychology and cognitive sciences, Neurofibromatosis, Theta Rhythm, neoplasms, Neuronal Plasticity, business.industry, 05 social sciences, Motor Cortex, Long-term potentiation, Middle Aged, medicine.disease, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Sensory Systems, nervous system diseases, Transcranial magnetic stimulation, Neurology, Synaptic plasticity, Cortical Excitability, Silent period, Female, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery, Neurotypical |
| الوصف: | Objective Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder that is associated with cognitive disabilities. Based on studies involving animals, the hypothesized cause of these disabilities results from increased activity of inhibitory interneurons that decreases synaptic plasticity. We obtained transcranial magnetic stimulation (TMS)-based measures of cortical inhibition, excitability and plasticity in individuals with NF1. Methods We included 32 NF1 adults and 32 neurotypical controls. Cortical inhibition was measured with short-interval intracortical inhibition (SICI) and cortical silent period (CSP). Excitability and plasticity were studied with intermittent theta burst stimulation (iTBS). Results The SICI and CSP response did not differ between NF1 adults and controls. The response upon iTBS induction was significantly increased in controls (70%) and in NF1 adults (83%). This potentiation lasted longer in controls than in individuals with NF1. Overall, the TMS response was significantly lower in NF1 patients (F(1, 41) = 7.552, p = 0.009). Conclusions Individuals with NF1 may have reduced excitability and plasticity, as indicated by their lower TMS response and attenuation of the initial potentiated response upon iTBS induction. However, our findings did not provide evidence for increased inhibition in NF1 patients. Significance These findings have potential utility as neurophysiological outcome measures for intervention studies to treat cognitive deficits associated with NF1. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1872-8952 1388-2457 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c269749315f03c1db655ec1cf0ee441aTest https://doi.org/10.1016/j.clinph.2020.08.016Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c269749315f03c1db655ec1cf0ee441a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18728952 13882457 |
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