Isokinetic Muscle Strength in Long-Term IDDM Patients in Relation to Diabetic Complications
| العنوان: | Isokinetic Muscle Strength in Long-Term IDDM Patients in Relation to Diabetic Complications |
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| المؤلفون: | Carl Erik Mogensen, Henning Andersen, Per Løgstrup Poulsen, Johannes Jakobsen |
| المصدر: | Diabetes. 45:440-445 |
| بيانات النشر: | American Diabetes Association, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, Male, Wrist Joint, medicine.medical_specialty, Weakness, Knee Joint, Movement, Endocrinology, Diabetes and Metabolism, Neural Conduction, Isometric exercise, Vibration, Diabetic Neuropathies, Reference Values, Isometric Contraction, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Muscle, Skeletal, Diabetic Retinopathy, business.industry, Diabetic retinopathy, Middle Aged, musculoskeletal system, medicine.disease, Surgery, body regions, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Peripheral neuropathy, Albuminuria, Cardiology, Regression Analysis, Female, Perception, medicine.symptom, Ankle, business, Retinopathy |
| الوصف: | The isokinetic muscle strength in 56 IDDM patients with > 20 years of diabetes duration and in their individually sex-, age-, weight-, and height-matched control subjects was assessed. Peak torque of foot dorsal and plantar flexion and knee and wrist extension and flexion was measured. The neuropathic condition was assessed by a neurological disability score, a neuropathy symptom score, nerve conduction studies, and quantitative sensory examination. All results were summed to obtain a neuropathy rank-sum score for each patient. According to their renal albumin excretion, the patients were classified to have normo-, micro-, or macroalbuminuria. In addition, according to their retinal status, patients were classified as having no, simple, or proliferative retinopathy. The IDDM patients had a 21% reduction of muscle strength of both ankle dorsal (P < 1 × 10™4) and plantar flexors (P < 0.01), compared with control subjects. A 16% reduction of knee extensors (P < 0.005) and a 17% reduction of knee flexors (P < 0.01) was found. In contrast, muscle strength in wrist flexors and extensors was not significantly reduced (10 and 11%, respectively [NS]). In patients with the most severe weakness, muscle strength of the calf muscles was only 50% of the expected performance. Correlations were found between the neuropathy rank-sum score and the muscle strength of ankle dorsal (r = −0.66, P < 1 × 10™7) and plantar flexors (r = −0.51, P < 0.0005), knee extensors (r = −0.51, P < 0.0005) and flexors (r = −0.44, P < 0.005), and wrist flexors (r = −0.41, P < 0.005). No correlation was found for wrist extensors (r = 0). Neither were there any relationships between muscle strength at the ankle and knee and the degree of albuminuria or retinopathy. In conclusion, motor performance is substantially impaired in long-term IDDM patients, and the weakness is related to the presence of neuropathy but not to albuminuria or retinopathy per se. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cff7ef56fa70be06cb4bb6f5318728Test https://doi.org/10.2337/diab.45.4.440Test |
| رقم الانضمام: | edsair.doi.dedup.....c1cff7ef56fa70be06cb4bb6f5318728 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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