The First Korean Case of Disseminated Mycetoma Caused by Nocardia pseudobrasiliensis in a Patient on Long-Term Corticosteroid Therapy for the Treatment of Microscopic Polyangiitis
| العنوان: | The First Korean Case of Disseminated Mycetoma Caused by Nocardia pseudobrasiliensis in a Patient on Long-Term Corticosteroid Therapy for the Treatment of Microscopic Polyangiitis |
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| المؤلفون: | Chang Ahn Seol, Yong Pil Chong, Duck Hee Kim, Misuk Ji, Mi Na Kim, Heungsup Sung |
| المصدر: | Annals of Laboratory Medicine |
| بيانات النشر: | Annals of Laboratory Medicine, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.drug_class, hsp65, Clinical Biochemistry, Antibiotics, Microscopic Polyangiitis, Case Report, Nocardia, Microbiology, Asian People, Bacterial Proteins, Adrenal Cortex Hormones, RNA, Ribosomal, 16S, Ampicillin, Republic of Korea, medicine, Corticosteroids, Humans, Skin, Scalp, integumentary system, biology, Nocardia brasiliensis, Biochemistry (medical), Nocardiosis, Sequence Analysis, DNA, General Medicine, Sulbactam, Middle Aged, Amoxicillin, bacterial infections and mycoses, biology.organism_classification, medicine.disease, Clinical Microbiology, Mycetoma, Female, Microscopic polyangiitis, Nocardia pseudobrasiliensis, 16S ribosomal RNA, medicine.drug |
| الوصف: | Nocardia pseudobrasiliensis is predominantly associated with invasive infections in immunocompromised patients. We report a case of disseminated mycetoma caused by N. pseudobrasiliensis in a 57-yr-old woman with microscopic polyangiitis, who was treated for 3 months with corticosteroids. The same organism was isolated from mycetoma cultures on the patient's scalp, right arm, and right leg. The phenotypic characteristics of the isolate were consistent with both Nocardia brasiliensis and N. pseudobrasiliensis, i.e., catalase and urease positivity, hydrolysis of esculin, gelatin, casein, hypoxanthine, and tyrosine, but no hydrolysis of xanthine. The isolate was identified as N. pseudobrasiliensis based on 16S rRNA and hsp65 gene sequencing. The patient was treated for 5 days with intravenous ampicillin/sulbactam, at which time both the mycetomas and fever had subsided and discharged on amoxicillin/clavulanate. This case highlights a very rare presentation of mainly cutaneous mycetoma caused by N. pseudobrasiliensis. This is the first reported case of N. pseudobrasiliensis infection in Korea. |
| تدمد: | 2234-3814 2234-3806 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b73e2cfe5f0b71cc9b310de8575eb6Test https://doi.org/10.3343/alm.2013.33.3.203Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c1b73e2cfe5f0b71cc9b310de8575eb6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22343814 22343806 |
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