A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke
| العنوان: | A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke |
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| المؤلفون: | Xi-Xi Gu, Chun-Hong Liu, Ye-Sheng Wei, Yan Wang, Hua-Tuo Huang |
| المصدر: | Lipids in Health and Disease Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-8 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, medicine.medical_specialty, Genotype, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Single-nucleotide polymorphism, Clinical nutrition, Polymorphism, Single Nucleotide, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, NEFA, Internal medicine, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Polymorphism, Promoter Regions, Genetic, lcsh:RC620-627, Aged, Metastasis associated lung adenocarcinoma transcript 1, Ischemic stroke, business.industry, Research, Biochemistry (medical), Haplotype, Middle Aged, medicine.disease, Stroke, lcsh:Nutritional diseases. Deficiency diseases, 030104 developmental biology, Haplotypes, Adenocarcinoma, Female, RNA, Long Noncoding, business, 030217 neurology & neurosurgery, Lipidology |
| الوصف: | Background Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases. Particularly in ischemic stroke (IS), the abnormal expression of MALAT1 played important roles including promotion of angiogenesis, inhibition of apoptosis and inflammation and regulation of autophagy. However, the effects of genetic variation (single nucleotide polymorphisms, SNPs) of MALAT1 on IS have rarely been explored. This study aimed to investigate whether SNPs in promoter of MALAT1 were associated with the susceptibility to IS. Methods A total of 316 IS patients and 320 age-, gender-, and ethnicity-matched controls were enrolled in this study. Four polymorphisms in the promoter of MALAT1 (i.e., rs600231, rs1194338, rs4102217, and rs591291) were genotyped by using a custom-by-design 48-Plex SNPscan kit. Results The rs1194338 C > A variant in the promoter of MALAT1 was associated with the risk of IS (AC vs. CC: adjusted OR = 0.623, 95% CI, 0.417–0.932, P = 0.021; AA vs. CC: adjusted OR = 0.474, 95% CI, 0.226–0.991, P = 0.047; Dominant model: adjusted OR = 0.596, 95% CI, 0.406–0.874, P = 0.008; A vs. C adjusted OR = 0.658, 95% CI, 0.487–0.890, P = 0.007). The haplotype analysis showed that rs600231-rs1194338-rs4102217-rs591291 (A-C-G-C) had a 1.3-fold increased risk of IS (95% CI, 1.029–1.644, P = 0.027). Logistic regression analysis identified some independent impact factors for IS including rs1194338 AC/AA, TC, TG, HDL-C, LDL-C, Apo-A1, Apo-B and NEFA (P Conclusions These results suggest that the rs1194338 AC/AA genotypes may be a protective factor for IS. |
| تدمد: | 1476-511X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10dd5171fd3f79cb4f080237d821b55Test https://pubmed.ncbi.nlm.nih.gov/32238151Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c10dd5171fd3f79cb4f080237d821b55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1476511X |
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