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Non-Carbapenem Antibiotics to Treat Severe Extended-Spectrum-β- Lactamase-Producing Enterobacteriaceae Infections in Intensive Care Unit Patients

التفاصيل البيبلوغرافية
العنوان:	Non-Carbapenem Antibiotics to Treat Severe Extended-Spectrum-β- Lactamase-Producing Enterobacteriaceae Infections in Intensive Care Unit Patients
المؤلفون:	Guillaume Hékimian, Sébastien Besset, Florent Huang, Charles-Edouard Luyt, Alexandra Aubry, Morgane Faure, Jean Chastre, Helga Junot, Matthieu Schmidt, Isabelle Bonnet, Julien Mayaux, Nicolas Bréchot, Alain Combes
المساهمون:	Service de Réanimation Médicale [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Bactériologie et d'Hygiène Hospitalière [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gestionnaire, Hal Sorbonne Université, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Immunologie et des Maladies Infectieuses (CIMI)
المصدر:	International Journal of Antimicrobial Agents International Journal of Antimicrobial Agents, Elsevier, 2019, 53 (5), pp.547-552. ⟨10.1016/j.ijantimicag.2019.02.001⟩ International Journal of Antimicrobial Agents, 2019, 53 (5), pp.547-552. ⟨10.1016/j.ijantimicag.2019.02.001⟩
بيانات النشر:	HAL CCSD, 2019.
سنة النشر:	2019
مصطلحات موضوعية:	Male, 0301 basic medicine, Carbapenem, Antibiotics, Antimicrobial stewardship, law.invention, 0302 clinical medicine, Recurrence, law, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, polycyclic compounds, Pharmacology (medical), Treatment Failure, 030212 general & internal medicine, Mortality rate, Enterobacteriaceae Infections, General Medicine, Middle Aged, Clostridium difficile, Intensive care unit, Anti-Bacterial Agents, 3. Good health, Intensive Care Units, Infectious Diseases, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, medicine.drug, Microbiology (medical), medicine.medical_specialty, medicine.drug_class, Critical Illness, Secondary infection, 030106 microbiology, beta-Lactamases, 03 medical and health sciences, Enterobacteriaceae, Extended-spectrum β-lactamase, Carbapenem-sparing agent, Internal medicine, medicine, Humans, Aged, Retrospective Studies, business.industry, Retrospective cohort study, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Survival Analysis, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, bacteria, business
الوصف:	International audience; OBJECTIVES: The aim of this study was to evaluate the use of non-carbapenem antibiotics to treat severe extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) infections in intensive care unit (ICU) patients.METHODS: This retrospective observational study conducted in two ICUs compared the outcomes of patients with ESBL-E infections administered a carbapenem or a non-carbapenem antibiotic as their definitive treatment. The primary outcome was treatment failure within 30 days, a composite endpoint of ESBL-E infection recurrence and 30-day mortality. Secondary outcomes included 30-day and in-hospital mortality rates, ESBL-E infection recurrence and infection(s) due to other pathogen(s).RESULTS: Among 107 patients included in the study, 67 received a carbapenem and 40 received a non-carbapenem antibiotic as their definitive treatment. Clinical characteristics of the two groups were similar. Comparing patients given a non-carbapenem antibiotic with those administered a carbapenem, they had similar 30-day treatment failure (43% vs. 61%, respectively; P = 0.06) and ESBL-E infection recurrence rates (25% vs. 22%; P = 0.8), but the former had lower 30-day mortality (23% vs. 45%; P = 0.02) and in-hospital mortality rates (23% vs. 49%; P = 0.005). Secondary infection rates caused by other pathogen(s), including Clostridium difficile, were comparable. Outcomes were comparable regardless of whether or not patients received an empirical carbapenem.CONCLUSION: For ICU patients with severe ESBL-E infections, treatment with a non-carbapenem antibiotic was not associated with poorer outcomes compared with a carbapenem antibiotic.
وصف الملف:	application/pdf
اللغة:	English
تدمد:	0924-8579
الوصول الحر:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fa8268f6e4a8b5005c344c2f7b2ac5Test https://hal.sorbonne-universite.fr/hal-02272285/documentTest
حقوق:	OPEN
رقم الانضمام:	edsair.doi.dedup.....c0fa8268f6e4a8b5005c344c2f7b2ac5
قاعدة البيانات:	OpenAIRE

الوصف
تدمد:	09248579