Infant gut microbiota characteristics generally do not modify effects of lipid-based nutrient supplementation on growth or inflammation: secondary analysis of a randomized controlled trial in Malawi
| العنوان: | Infant gut microbiota characteristics generally do not modify effects of lipid-based nutrient supplementation on growth or inflammation: secondary analysis of a randomized controlled trial in Malawi |
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| المؤلفون: | Kenneth Maleta, Charles D Arnold, Rebecca R Young, Kathryn G. Dewey, Yue-Mei Fan, Chikondi Malamba-Banda, Ulla Ashorn, David Chaima, Mary E. Kable, Per Ashorn, Riley L Hughes |
| المساهمون: | Tampere University, Department of Paediatrics, Clinical Medicine |
| المصدر: | Scientific reports, vol 10, iss 1 Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Malawi, Epidemiology, Physiology, lcsh:Medicine, Gut flora, medicine.disease_cause, Oral and gastrointestinal, law.invention, Cohort Studies, Feces, 0302 clinical medicine, Randomized controlled trial, law, 3123 Gynaecology and paediatrics, Medicine, 030212 general & internal medicine, Micronutrients, lcsh:Science, Infant Nutritional Physiological Phenomena, Pediatric, Multidisciplinary, biology, Streptococcus, Micronutrient, Lipids, Female, medicine.symptom, Firmicutes, Clinical Trials and Supportive Activities, Mothers, Nutritional Status, Inflammation, Paediatric research, Policy and public health in microbiology, Article, Applied microbiology, 03 medical and health sciences, Clinical Research, Complementary and Integrative Health, Humans, Nutrition, business.industry, Ruminococcus, lcsh:R, Infant, Maternal Nutritional Physiological Phenomena, biology.organism_classification, Gastrointestinal Microbiome, 3141 Health care science, 030104 developmental biology, Dietary Supplements, lcsh:Q, business |
| الوصف: | An unhealthy gut microbial community may act as a barrier to improvement in growth and health outcomes in response to nutritional interventions. The objective of this analysis was to determine whether the infant microbiota modified the effects of a randomized controlled trial of lipid-based nutrient supplements (LNS) in Malawi on growth and inflammation at 12 and 18 months, respectively. We characterized baseline microbiota composition of fecal samples at 6 months of age (n = 506, prior to infant supplementation, which extended to 18 months) using 16S rRNA gene sequencing of the V4 region. Features of the gut microbiota previously identified as being involved in fatty acid or micronutrient metabolism or in outcomes relating to growth and inflammation, especially in children, were investigated. Prior to correction for multiple hypothesis testing, the effects of LNS on growth appeared to be modified by Clostridium (p-for-interaction = 0.02), Ruminococcus (p-for-interaction = 0.007), and Firmicutes (p-for-interaction = 0.04) and effects on inflammation appeared to be modified by Faecalibacterium (p-for-interaction = 0.03) and Streptococcus (p-for-interaction = 0.004). However, after correction for multiple hypothesis testing these findings were not statistically significant, suggesting that the gut microbiota did not alter the effect of LNS on infant growth and inflammation in this cohort. |
| وصف الملف: | fulltext; application/pdf |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f33c467c86fdbe946039391ffd3d6dTest https://pubmed.ncbi.nlm.nih.gov/32908192Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0f33c467c86fdbe946039391ffd3d6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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